Pharmacognosy Magazine

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 15  |  Issue : 65  |  Page : 736--739

Chemical composition from the leaves of Lindera fragrans Oliv.


He-Zhong Jiang1, Tian Gan1, Ya-Nan Li1, Chun-Yan Du1, Jun-Long Li2, Jun-Ting Fan3, Rui Tan1 
1 School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, China
2 Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu, China
3 Department of Pharmaceutical Analysis, School of Pharmacy, Nanjing Medical University, Nanjing, China

Correspondence Address:
He-Zhong Jiang
School of Life Science and Engineering, Southwest Jiaotong University, Chengdu
China
Rui Tan
School of Life Science and Engineering, Southwest Jiaotong University, Chengdu
China

Background: One hundred known species belong to the genus Lindera (Lauraceae) and rich in chemical structure types. The branch leaves of Lindera fragrans Oliv. show the special curative effect of treating gastroenteritis and gastric ulcer. There are not comparatively detailed reports carried on studying the chemical composition and bioactivity of L.fragrans. Objective: This paper reports the chemical investigation and biological evaluation of the L.fragrans. Materials and Methods: The petroleum ether and ethyl acetate soluble part of L.fragrans was isolated using chromatographic methods, and the structures of these compounds were identified by comparison of their spectroscopic data with those reported in the literature. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide method was used to determine the antitumor activity of the isolated compounds. Results: Twelve compounds were isolated from the leaves of L.fragrans and classified as six alkaloids (1–6), three flavonoids (7–9), two aromatics (10 and 11), and one anthraquinone (12). The study of antitumor activity showed that compounds 3–5 had weak antitumor activities with the half maximal inhibitory values ranging from 71.97 to 94.69 μM. Conclusion: All of these compounds were isolated from this plant for the first time and compounds 3–6, 8, and 9 were first reported from the genus Lindera. Compounds 3–5 exhibited weak antitumor activities. The chemical investigation of the leaves of Lindera fragrans resulted in the isolation of 12 compounds including six alkaloids (1–6), three flavonoids (7–9), two aromatics (10 and 11), one anthraquinone (12). The isolated compounds 3–9 were evaluated for their cytotoxicity against melanoma, glioma, and hepatoma cells by MTT method.


How to cite this article:
Jiang HZ, Gan T, Li YN, Du CY, Li JL, Fan JT, Tan R. Chemical composition from the leaves of Lindera fragrans Oliv. Phcog Mag 2019;15:736-739


How to cite this URL:
Jiang HZ, Gan T, Li YN, Du CY, Li JL, Fan JT, Tan R. Chemical composition from the leaves of Lindera fragrans Oliv. Phcog Mag [serial online] 2019 [cited 2020 Jan 22 ];15:736-739
Available from: http://www.phcog.com/article.asp?issn=0973-1296;year=2019;volume=15;issue=65;spage=736;epage=739;aulast=Jiang;type=0