Pharmacognosy Magazine

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 15  |  Issue : 65  |  Page : 708--714

Effects of selected moraceae plants on tyrosinase enzyme and melanin content


Sukanya Dej-adisai1, Kedsaraporn Parndaeng1, Chatchai Wattanapiromsakul1, Wanlapa Nuankaew2, Tong Ho Kang2 
1 Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla, Thailand
2 Department of Oriental Medicinal Biotechnology, Graduate School of Biotechnology, College of Life Sciences, Kyung Hee University, Gyeonggi-do, Republic of Korea

Correspondence Address:
Sukanya Dej-adisai
Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla 90112
Thailand

Background: Hyperpigmentation is the one cause of skin disorder. The dark-colored skin causes from the increasing of melanin pigment production. It is synthesized by melanogenesis catalyzed by tyrosinase enzyme. Tyrosinase is one of the main causes of melanogenesis; thus, inhibition of the activity of tyrosinase can decrease melanogenesis. Hence, the potential tyrosinase inhibitor could be discovered from natural products. Objective: Discovery of tyrosinase inhibitor from natural products by focusing on Moraceae plants. Materials and Methods: Forty-eight Moraceae plant extracts were screened for antityrosinase and antibacterial activities; Streblus taxoides and Artocarpus chama were selected to study in B16F1 melanoma cell; intracellular antityrosinase activity and melanin content. Moreover, pigmentation inhibitory effect on the zebrafish of these samples was studied. Results: The extracts of S. taxoides and A. chama showed the potential activity against tyrosinase enzyme on both intracellular and extracellular enzymatic assays. Moreover, they suppressed pigmentation in zebrafish. Only ethyl acetate extract of these plants could show anti-bacterial activity. Conclusion: S. taxoides and A. chama are potential plants for further study of chemical constituents and biological activities especially the anti-tyrosinase activity of the isolated compound to find out the lead compound for whitening agent from natural product.


How to cite this article:
Dej-adisai S, Parndaeng K, Wattanapiromsakul C, Nuankaew W, Kang TH. Effects of selected moraceae plants on tyrosinase enzyme and melanin content.Phcog Mag 2019;15:708-714


How to cite this URL:
Dej-adisai S, Parndaeng K, Wattanapiromsakul C, Nuankaew W, Kang TH. Effects of selected moraceae plants on tyrosinase enzyme and melanin content. Phcog Mag [serial online] 2019 [cited 2019 Nov 19 ];15:708-714
Available from: http://www.phcog.com/article.asp?issn=0973-1296;year=2019;volume=15;issue=65;spage=708;epage=714;aulast=Dej-adisai;type=0