Pharmacognosy Magazine

ORIGINAL ARTICLE
Year
: 2016  |  Volume : 12  |  Issue : 45  |  Page : 21--24

Comparative pharmacokinetics of ginsenoside Rg3 and ginsenoside Rh2 after oral administration of ginsenoside Rg3 in normal and walker 256 tumor-bearing rats


He Fan1, Sun Xiao-ling2, Su Yaliu1, Lu Ming-ming3, Feng Xue3, Meng Xian-sheng1, Fu Li3 
1 Department of Chinese Medicine Analysis, Liaoning University of Traditional Chinese Medicine, 77 Life One Road, DD Port, Dalian 116600, China
2 Institute of Traditional Chinese Medicine, Liaoning Institute for Drug Control, 7 Congshan West Road, Shenyang 110036, China
3 Dalian Fusheng Natural Drug Development Co., Ltd, 5 Tiexi Middle Road, Development District, Dalian 116600, China

Correspondence Address:
Fu Li
Dalian Fusheng Natural Drug Development Co., Ltd., 5 Tiexi Middle Road, Development District, Dalian 116600
China

Background: Ginseng is Chinese traditional herbal medicine, and the ginsenoside Rg 3 is the main bioactive ingredient for the anti-tumor effect. However, there is no study on pharmacokinetics (PKs) of ginsenoside Rg 3 and its main metabolite after oral ginsenoside Rg 3 in tumor-bearing plasma. The aim of this study was to investigate the PK profiles of ginsenoside Rg 3 and ginsenoside Rh 2 after oral administration of pure ginsenoside Rg 3 were administered, and compare the difference of the PK profiles between normal and Walker 256 tumor-bearing rats. Materials and Methods: The concentrations of two ginsenosides in plasma were determined by using a simple and rapid high-performance liquid chromatography. All the rats were divided randomly into two groups (Walker 256 tumor-bearing and normal groups). Each group received oral administration of 50 mg/kg ginsenoside Rg 3 . Results: The results showed that ginsenoside Rh 2, possibly as a glycosylation hydrolysis product of ginsenoside Rg 3, were found in plasma after oral administration of ginsenoside Rg 3 to rats. Ginsenoside Rg 3 had shown better absorption than ginsenoside Rh 2, whether the oral administration of ginsenoside Rg 3 , normal rats showed better absorption than tumor-bearing rats. Discussion and Conclusion: The PKs properties of the ginsenoside Rg 3 and ginsenoside Rh 2 differed between tumor-bearing rats and normal rats, including area under the plasma level/time curve and concentration maximum (P < 0.05).


How to cite this article:
Fan H, Xiao-ling S, Yaliu S, Ming-ming L, Xue F, Xian-sheng M, Li F. Comparative pharmacokinetics of ginsenoside Rg3 and ginsenoside Rh2 after oral administration of ginsenoside Rg3 in normal and walker 256 tumor-bearing rats.Phcog Mag 2016;12:21-24


How to cite this URL:
Fan H, Xiao-ling S, Yaliu S, Ming-ming L, Xue F, Xian-sheng M, Li F. Comparative pharmacokinetics of ginsenoside Rg3 and ginsenoside Rh2 after oral administration of ginsenoside Rg3 in normal and walker 256 tumor-bearing rats. Phcog Mag [serial online] 2016 [cited 2020 Mar 28 ];12:21-24
Available from: http://www.phcog.com/article.asp?issn=0973-1296;year=2016;volume=12;issue=45;spage=21;epage=24;aulast=Fan;type=0