Pharmacognosy Magazine

ORIGINAL ARTICLE
Year
: 2014  |  Volume : 10  |  Issue : 39  |  Page : 314--317

Antitumor effects of dammarane-type saponins from steamed Notoginseng


Fan He1, Yan Ding2, Chun Liang3, Seok Bean Song4, De-Qiang Dou1, Gyu Yong Song4, Young Ho Kim4 
1 Department of Pharmacognosy, Liaoning University of Traditional Chinese Medicine, Dalian, China
2 Institute of Chemistry and Applications of Plant Resources, Dalian Polytechnic University, Dalian, China
3 Herbal Medicine Improvement Research Center, Korea Institute of Oriental Medicine, Daejeon, Korea
4 College of Pharmacy, Chungnam National University, Daejeon, Korea

Correspondence Address:
Young Ho Kim
College of Pharmacy, Chungnam National University, Daejeon 305 764
Korea

Six dammarane-type saponins were extracted from steamed Panax notoginseng. Their chemical structures were identified spectroscopically as ginsenosides Rh 1 (1), Rg 1 (2), 20 (S)-Rg 3 (3), 20 (R)-Rg 3 (4), Rb 3 (5), and Rb 1 (6). Compounds (0.1-10 μM) were tested for inhibition of tumor necrosis factor-α (TNF)-induced nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) luciferase reporter activity using a human kidney 293T cell-based assay. Ginsenoside Rb 3 (5) showed the most significant activity with an IC 50 of 8.2 μM. This compound also inhibited the induction of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) messenger Ribonucleic acid (mRNA) in a dose-dependent manner after HepG2 cells had been treated with TNF-α (10 ng/mL).


How to cite this article:
He F, Ding Y, Liang C, Song SB, Dou DQ, Song GY, Kim YH. Antitumor effects of dammarane-type saponins from steamed Notoginseng.Phcog Mag 2014;10:314-317


How to cite this URL:
He F, Ding Y, Liang C, Song SB, Dou DQ, Song GY, Kim YH. Antitumor effects of dammarane-type saponins from steamed Notoginseng. Phcog Mag [serial online] 2014 [cited 2020 Jul 11 ];10:314-317
Available from: http://www.phcog.com/article.asp?issn=0973-1296;year=2014;volume=10;issue=39;spage=314;epage=317;aulast=He;type=0