Pharmacognosy Magazine

ORIGINAL ARTICLE
Year
: 2014  |  Volume : 10  |  Issue : 39  |  Page : 217--226

Preparation and pharmacokinetics in beagle dogs of ganershu sustained-release pellets


Jin-huo Pan1, Jian-chun Wang3, Zhi-tao Jiang3, Ting Zhang2, Shao-bo Ge2, Ye-xia Zhang2, Xin Jin3, Guo-jun Yan2 
1 College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023; Department of Pharmacy Office, Traditional Chinese Medicine Hospital of Zhang-jia-gang, Zhangjiagang 215600, China
2 College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
3 Department of Pharmacy Office, The First People's Hospital of Suqian, Suqian 223800, China

Correspondence Address:
Guo-jun Yan
College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023
China

Background: The active ingredients of Ganershu compound recipe, which are effective for hepatitis treatment in liver protection and transaminase reduction. However, the active ingredients of Ganershu compound recipe are poor absorption, which conduct it has a low oral bioavailability. Objective: We prepared Ganershu sustained-release pellets (GSPs) by fluidized-bed on central composite design-response surface methodology and increase its bioavailability in beagle dogs. Materials and Methods: In this study, GSPs were successfully prepared. The Drug-loaded pellets and sustained-release coated were carried out in fluidized-bed machine. GSP was optimized for fitting release, roundness, and the overall desirability by central composite design-response surface methodology. Results: To optimize cumulative release profile, the outermost ethyl cellulose coating layer and the hydroxypropyl methyl cellulose (HPMC) swelling layer were employed, which were respectively given coating levels in terms of weight gain of 22% and 6%, the concentration of HPMC is 4.5% (g/ml). The pharmacokinetics of Ganershu normal pellets (GNPs) and GSP was studied in beagle dogs after oral administration. The naringenin as an index, the area under the curve 0-∞ of naringenin in GSP was 1.38 times greater than that of GNP. Meanwhile, Tmax of GSP was prolonged for about 74%. Conclusion: This study can clearly indicate that we enhanced the oral bioavailability of Ganershu by preparing the GSP, which had the sustained dissolution and improved the potential of it for clinical application.


How to cite this article:
Pan Jh, Wang Jc, Jiang Zt, Zhang T, Ge Sb, Zhang Yx, Jin X, Yan Gj. Preparation and pharmacokinetics in beagle dogs of ganershu sustained-release pellets.Phcog Mag 2014;10:217-226


How to cite this URL:
Pan Jh, Wang Jc, Jiang Zt, Zhang T, Ge Sb, Zhang Yx, Jin X, Yan Gj. Preparation and pharmacokinetics in beagle dogs of ganershu sustained-release pellets. Phcog Mag [serial online] 2014 [cited 2020 Jul 5 ];10:217-226
Available from: http://www.phcog.com/article.asp?issn=0973-1296;year=2014;volume=10;issue=39;spage=217;epage=226;aulast=Pan;type=0