Pharmacognosy Magazine

ORIGINAL ARTICLE
Year
: 2014  |  Volume : 10  |  Issue : 38  |  Page : 214--216

Aqueous extract from taxus baccata inhibits adenosine deaminase activity significantly in cancerous and noncancerous human gastric and colon tissues


Zahide Esra Durak1, Suleyman Buber2, Erdinc Devrim2, Hilmi Kocaoglu3, Ilker Durak2 
1 Ordu University Centre Research Laboratory, Ordu, Turkey
2 Department of Medical Biochemistry, Ankara University Faculty of Medicine, Ankara, Turkey
3 Department of Surgical Oncology, Ankara University Faculty of Medicine, Ankara, Turkey

Correspondence Address:
Ilker Durak
Ankara Universitesi Tip Fakultesi, Tibbi Biyokimya Anabilim Dali,Dekanlik Binasi, Sihhiye / 06100, Ankara
Turkey

Objective: To investigate possible effects of aqueous taxus baccata extract on adenosine deaminase (ADA) activity in cancerous and noncancerous human tissues and to clarify mechanism(s) of its anticancer potential. Materials and Methods: Cancerous and noncancerous human gastric and colon tissues were used in the study. The extracts were prepared in distilled water. Before and after treatment with the extracts, ADA activities in the tissue homogenates were measured. Results: ADA activity was found to be higher in gastric tissue compared with colon tissue, but no differences were found between ADA activities of cancerous and noncancerous tissues for both as well. In the plant extract studies, it was found that taxus extract significantly inhibited ADA activity both in cancerous and noncancerous gastric and colon tissues. Conclusion: Our results suggest that aqueous extract from taxus baccata inhibits ADA activities in both gastric and colon tissues significantly. It is suggested that in addition to other proposed mechanisms, accumulated adenosine due to the inhibition of ADA enzyme might also play part in the anticancer properties of taxus species.


How to cite this article:
Durak ZE, Buber S, Devrim E, Kocaoglu H, Durak I. Aqueous extract from taxus baccata inhibits adenosine deaminase activity significantly in cancerous and noncancerous human gastric and colon tissues.Phcog Mag 2014;10:214-216


How to cite this URL:
Durak ZE, Buber S, Devrim E, Kocaoglu H, Durak I. Aqueous extract from taxus baccata inhibits adenosine deaminase activity significantly in cancerous and noncancerous human gastric and colon tissues. Phcog Mag [serial online] 2014 [cited 2019 Nov 22 ];10:214-216
Available from: http://www.phcog.com/article.asp?issn=0973-1296;year=2014;volume=10;issue=38;spage=214;epage=216;aulast=Durak;type=0