Pharmacognosy Magazine

ORIGINAL ARTICLE
Year
: 2013  |  Volume : 9  |  Issue : 36  |  Page : 66--73

Mitigation of starch and glucose-induced postprandial glycemic excursion in rats by antioxidant-rich green-leafy vegetables«SQ» juice


Ashok Kumar Tiwari1, Atmakuri Lakshmana Jyothi1, Vasantharao Brahma Tejeswini1, Kuncha Madhusudana1, Domati Anand Kumar1, Amtul Zehra1, Sachin Bharat Agawane2 
1 Medicinal Chemistry and Pharmacology Division, CSIR Indian Institute of Chemical Technology, Hyderabad, India
2 Medicinal Chemistry and Pharmacology Division, CSIR Indian Institute of Chemical Technology, Hyderabad; Present address: Biochemical Sciences Division, CSIR National Chemical Laboratory, Pune, India

Correspondence Address:
Ashok Kumar Tiwari
Principal Scientist, Medicinal Chemistry and Pharmacology Division, CSIR Indian Institute of Chemical Technology, Hyderabad - 500 007
India

Objective: Consumption of green-leafy vegetables is being advocated beneficial for type 2 diabetes mellitus individuals possibly because they are cost effective source of potent biological antioxidants. This research analyzed various phytochemicals, free radicals scavenging antioxidant potentials and starch digesting enzymes inhibitory activities in fresh juice of nine green-leafy vegetables. Furthermore, this study also investigated influence of these vegetables juice on starch and glucose induced postprandial glycemic load. Materials and Methods: Phytochemical constituents, in vitro free radicals scavenging antioxidant and enzymes inhibitory activities were evaluated applying various reported methods. Post-prandial glycemic excursion was induced in rats pretreated with vegetables juice by oral administration of starch and glucose. Results: All the leafy vegetables juice displayed potent free radicals scavenging activities. Juice of amaranthus, rumex, palak and raphanus displayed potential anti-oxidative property by reducing H 2 O 2 induced hemolysis in rats red blood cells RBCs. Ajwain and rumex juice showed pancreatic α-amylase inhibitory activity. Alternanthera, ajwain, methi, amaranthus and sowa leaves juice displayed intestinal α-glucosidase inhibitory activity. Juice of raphanus, ajwain and sowa significantly mitigated starch-induced postprandial glycemic load. Amaranthus leaves juice potently mitigated glucose-induced postprandial glycemic load and also reduced hemoglobin glycation induced by glucose in vitro. Conclusions: This investigation finds that juice of leafy vegetables is potent source of biological antioxidants. In addition, juice of raphanus, ajwain and sowa leaves possess capacity to mitigate starch induced postprandial glycemic burden and amaranthus leaves«SQ» juice can reduce glucose induced postprandial glycemic excursion.


How to cite this article:
Tiwari AK, Jyothi AL, Tejeswini VB, Madhusudana K, Kumar DA, Zehra A, Agawane SB. Mitigation of starch and glucose-induced postprandial glycemic excursion in rats by antioxidant-rich green-leafy vegetables' juice.Phcog Mag 2013;9:66-73


How to cite this URL:
Tiwari AK, Jyothi AL, Tejeswini VB, Madhusudana K, Kumar DA, Zehra A, Agawane SB. Mitigation of starch and glucose-induced postprandial glycemic excursion in rats by antioxidant-rich green-leafy vegetables' juice. Phcog Mag [serial online] 2013 [cited 2020 Mar 29 ];9:66-73
Available from: http://www.phcog.com/article.asp?issn=0973-1296;year=2013;volume=9;issue=36;spage=66;epage=73;aulast=Tiwari;type=0