Pharmacognosy Magazine

ORIGINAL ARTICLE
Year
: 2011  |  Volume : 7  |  Issue : 28  |  Page : 334--337

Enhancement of the antibiotic activity of erythromycin by volatile compounds of Lippia alba (Mill.) N.E. Brown against Staphylococcus aureus


Helenicy N.H. Veras, Adriana R Campos, Fabíola F.G. Rodrigues, Marco A Botelho, Henrique D.M. Coutinho, Irwin R.A. Menezes, José Galberto M da Costa 
 Programa de Pós-Graduação em Bioprospecção Molecular - Laboratório de Pesquisas de Produtos Naturais - Universidade Regional do Cariri - CEP 63105-000 - Pimenta - Crato - Ceará, Brazil

Correspondence Address:
José Galberto M da Costa
Programa de Pós-Graduação em Bioprospecção Molecular, Departamento de Química Biológica, Laboratório de Pesquisa de Produtos Naturais, Universidade Regional do Cariri, Rua Cel. Antônio Luiz 1161, 63105-000 Crato-CE
Brazil

Background: Lippia alba (Mill.) N.E. Brown, popularly known as «DQ»erva-cidreira,«DQ» is commonly found in northeastern Brazil. The leaves tea is used to treat digestive disturbances, nausea, cough, and bronchitis. Objective: This work reports the chemical composition and erythromycin-modifying activity by gaseous contact against Staphylococcus aureus. Materials and Methods: The leaves of L. alba were subjected to hydrodistillation, and the essential oil extracted was examined with respect to the chemical composition, by gas chromatography-mass spectrometry (GC-MS), and the essential oil extracted was evaluated for antibacterial and antibiotic-modifying activity by gaseous contact. Results: The overall yield of essential oil obtained by hydrodistillation was 0.52%. The GC-MS analysis has led to the identification of the main components: geranial (31.4%) and neral (29.5%). It was verified that the essential oil interfered with erythromycin antibiotic activity against S. aureus ATCC 25923 was enhanced (221.4%) in the presence of 12% essential oil. The 3% essential oil increased the effect against S. aureus ATCC 25923 (41.6%) and S. aureus ATCC 6538 (58.3%). Conclusion: The essential oil of L. alba influences the activity of erythromycin and may be used as an adjuvant in antibiotic therapy against respiratory tract bacterial pathogens.


How to cite this article:
Veras HN, Campos AR, Rodrigues FF, Botelho MA, Coutinho HD, Menezes IR, da Costa JM. Enhancement of the antibiotic activity of erythromycin by volatile compounds of Lippia alba (Mill.) N.E. Brown against Staphylococcus aureus.Phcog Mag 2011;7:334-337


How to cite this URL:
Veras HN, Campos AR, Rodrigues FF, Botelho MA, Coutinho HD, Menezes IR, da Costa JM. Enhancement of the antibiotic activity of erythromycin by volatile compounds of Lippia alba (Mill.) N.E. Brown against Staphylococcus aureus. Phcog Mag [serial online] 2011 [cited 2019 Oct 17 ];7:334-337
Available from: http://www.phcog.com/article.asp?issn=0973-1296;year=2011;volume=7;issue=28;spage=334;epage=337;aulast=Veras;type=0