Pharmacognosy Magazine

ORIGINAL ARTICLE
Year
: 2011  |  Volume : 7  |  Issue : 28  |  Page : 314--319

Antioxidative effects of cinnamomi cortex: A potential role of iNOS and COX-II


Jin-Won Chung, Jeong-Jun Kim, Sung-Jin Kim 
 Department of Pharmacology and Toxicology, School of Dentistry, Kyung Hee University, Seoul 130-701, Korea

Correspondence Address:
Sung-Jin Kim
Department of Pharmacology and Toxicology, School of Dentistry, Kyung Hee University, Seoul 130-701
Korea

Background: Cinnamomi cortex has wide varieties of pharmacological actions such as anti-inflammatory action, anti-platelet aggregation, and improving blood circulation. In this study, we tested to determine whether the Cinnamomi cortex extract has antioxidant activities. Materials and Methods: Antioxidative actions were explored by measuring free radical scavenging activity, NO levels, and reducing power. The mechanism of antioxidative action of Cinnamomi cortex was determined by measuring iNOS and COX-II expression in lipopolysaccharide (LPS) stimulated Raw cells. Results: Seventy percent methanolic extract of Cinnamomi cortex exerted significant 1,1­diphenyl-­2-­picrylhydrazyl (DPPH) free radicals and NO scavenging activities in a dose-dependent manner. More strikingly, the Cinnamomi cortex extract exerted dramatic reducing power activity (13-fold over control). Production of iNOS induced by LPS was significantly inhibited by the Cinnamomi cortex extract, suggesting that it inhibits NO production by suppressing iNOS expression. Additionally, COX-2 induced by LPS was dramatically inhibited by the Cinnamomi cortex extract. Conclusion: These results suggest that 70% methanolic extract of Cinnamomi cortex exerts significant antioxidant activity via inhibiting iNOS and COX-II induction.


How to cite this article:
Chung JW, Kim JJ, Kim SJ. Antioxidative effects of cinnamomi cortex: A potential role of iNOS and COX-II.Phcog Mag 2011;7:314-319


How to cite this URL:
Chung JW, Kim JJ, Kim SJ. Antioxidative effects of cinnamomi cortex: A potential role of iNOS and COX-II. Phcog Mag [serial online] 2011 [cited 2019 Nov 18 ];7:314-319
Available from: http://www.phcog.com/article.asp?issn=0973-1296;year=2011;volume=7;issue=28;spage=314;epage=319;aulast=Chung;type=0