Pharmacognosy Magazine

ORIGINAL ARTICLE
Year
: 2011  |  Volume : 7  |  Issue : 28  |  Page : 284--288

Neuroprotective activity of the methanolic extract of Lonicera japonica in glutamate-injured primary rat cortical cells


Jin Bae Weon1, Hye Jin Yang1, Bohyoung Lee1, Bo-Ra Yun1, Ju Hee Ahn1, Hyeon Yong Lee1, Choong Je Ma2 
1 Department of Biomaterials Engineering, School of Bioscience and Biotechnology, Kangwon National University, Chuncheon, Korea
2 Department of Biomaterials Engineering, School of Bioscience and Biotechnology, Kangwon National University, Chuncheon; Research Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon 200-701, Korea

Correspondence Address:
Choong Je Ma
Department of Biomaterials Engineering, Division of Biotechnology and Bioengineering, Kangwon National University, Hyoja-2 Dong, Chuncheon 200-701
Korea

Background: We previously reported that the extracts of several Korean medicinal plants showed neuroprotective activity in glutamate-injured primary culutres of rat cortical cells. Objective: Among them, the effect of the methanolic extract of Lonicera japonica flower on the glutamate-induced neuronal cell death and its potential mechanism of action was investigated. Results: Treatment by the methanolic extract of L. japonica flower significantly protected neuronal cells against glutamate-induced excitotoxicity. It decreased the calcium influx that accompanies the glutamate induced excitotoxicity of neuronal cells, and inhibited the subsequent overproduction of nitric oxide, reactive oxygen species and peroxide to the level of control cells. In addition, it preserved cellular activity of superoxide dismutase, an antioxidative enzyme reduced by glutamate insult. Conclusions: According to this data, the methanolic extract of L. japonica flower significantly protected neuronal cells against glutamate excitotoxicity via antioxidative activity.


How to cite this article:
Weon JB, Yang HJ, Lee B, Yun BR, Ahn JH, Lee HY, Ma CJ. Neuroprotective activity of the methanolic extract of Lonicera japonica in glutamate-injured primary rat cortical cells.Phcog Mag 2011;7:284-288


How to cite this URL:
Weon JB, Yang HJ, Lee B, Yun BR, Ahn JH, Lee HY, Ma CJ. Neuroprotective activity of the methanolic extract of Lonicera japonica in glutamate-injured primary rat cortical cells. Phcog Mag [serial online] 2011 [cited 2019 Dec 13 ];7:284-288
Available from: http://www.phcog.com/article.asp?issn=0973-1296;year=2011;volume=7;issue=28;spage=284;epage=288;aulast=Weon;type=0