Pharmacognosy Magazine

ORIGINAL ARTICLE
Year
: 2010  |  Volume : 6  |  Issue : 23  |  Page : 219--224

Effect of Phlomis persica on glucose levels and hepatic enzymatic antioxidants in streptozotocin-induced diabetic rats


Parisa Sarkhail1, Mohammad Abdollahi1, Sedigheh Fadayevatan1, Abbas Shafiee1, Azadeh Mohammadirad1, Gholamreza Dehghan2, Hadi Esmaily1, Gholamreza Amin1 
1 Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
2 Department of Botany, Faculty of Natural Science, University of Tabriz, Tabriz, Iran

Correspondence Address:
Parisa Sarkhail
Pharmaceutical Sciences Research center, Tehran University of Medical Sciences, 16th Azar st, Tehran
Iran

Methanol extract of the aerial parts of Phlomis persica Boiss. (Lamiaceae) (PPE) was studied to evaluate the effects of antidiabetic potential, by measuring fasting blood glucose, insulin, total antioxidant power (TAP), using ferric reducing antioxidant power (FRAP), lipid peroxidation (using thiobarbituric acid reactive substances, TBARS), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) on streptozotocin-induced diabetes in rats. Male Wistar rats were randomly divided into five groups of six animals each. Oral administration of PPE at doses of 100 and 200 mg/kg once a day for 10 days resulted in a significant reduction in fasting blood glucose and an increase in serum insulin levels, in comparison with diabetic control group. It also prevented diabetes-induced loss in body weight. Hepatic TAP increased and TBARS decreased following PPE treatments. The extract at 100 and 200 mg/kg increased the activity of hepatic SOD, CAT, and GPx in diabetic rats. It is concluded that PPE has antidiabetic potential that is comparable with glibenclamide. In conclusion, the results of the present study show positive effects of P. persica on experimental diabetes and thus the antidiabetic effect of PPE is related to its potential to inhibit hepatocellular oxidative stress.


How to cite this article:
Sarkhail P, Abdollahi M, Fadayevatan S, Shafiee A, Mohammadirad A, Dehghan G, Esmaily H, Amin G. Effect of Phlomis persica on glucose levels and hepatic enzymatic antioxidants in streptozotocin-induced diabetic rats.Phcog Mag 2010;6:219-224


How to cite this URL:
Sarkhail P, Abdollahi M, Fadayevatan S, Shafiee A, Mohammadirad A, Dehghan G, Esmaily H, Amin G. Effect of Phlomis persica on glucose levels and hepatic enzymatic antioxidants in streptozotocin-induced diabetic rats. Phcog Mag [serial online] 2010 [cited 2020 Mar 28 ];6:219-224
Available from: http://www.phcog.com/article.asp?issn=0973-1296;year=2010;volume=6;issue=23;spage=219;epage=224;aulast=Sarkhail;type=0