Pharmacognosy Magazine

ORIGINAL ARTICLE
Year
: 2010  |  Volume : 6  |  Issue : 23  |  Page : 191--197

Preservation on calcium homeostasis is involved in mitochondrial protection of Limonium sinense against liver damage in mice


Xin-Hui Tang1, Jin Chen2, Xiao-Lan Yang4, Li-Fang Yan1, Jing Gao4 
1 Jiangsu Provincial Key Laboratory of Coastal Wetland Bioresources and Environmental Protection, Yancheng Teachers' University, 50 Kaifang Road, Yancheng, 224002, China; School of Pharmacy, Jiangsu University, 301 Xuefu Road, Zhenjiang, 212013, China
2 School of Life Science, Nanjing University, 22 Hankou Road, Nanjing, 210009, China; Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32816, USA

Correspondence Address:
Jing Gao
School of Pharmacy, Jiangsu University, 301 Xuefu Road, Zhenjiang, 212013, China

Mechanisms underlying the mitochondrial protection of Limonium sinense extracts (LSE) was studied in lipopolysaccharide and D-galactosamine (LPS/D-GalN) intoxicated mice. It was found that increased activities of serum aspartate aminotransferase and alanine aminotransferase induced by LPS/D-GalN were significantly inhibited by pretreatment with LSE. The obvious disruption of membrane potential, intramitochondrial Ca 2+ overload and suppression in mitochondrial Ca 2+ -ATPase activity induced by LPS/D-GalN were significantly blocked by pretreatment with LSE. It was concluded that mechanisms underlying protection of LSE against liver mitochondria damage might be related to the preservation on mitochondrial Ca 2+ homeostasis through the preservation on mitochondrial Ca 2+ -ATPase activity.


How to cite this article:
Tang XH, Chen J, Yang XL, Yan LF, Gao J. Preservation on calcium homeostasis is involved in mitochondrial protection of Limonium sinense against liver damage in mice.Phcog Mag 2010;6:191-197


How to cite this URL:
Tang XH, Chen J, Yang XL, Yan LF, Gao J. Preservation on calcium homeostasis is involved in mitochondrial protection of Limonium sinense against liver damage in mice. Phcog Mag [serial online] 2010 [cited 2019 Dec 9 ];6:191-197
Available from: http://www.phcog.com/article.asp?issn=0973-1296;year=2010;volume=6;issue=23;spage=191;epage=197;aulast=Tang;type=0