Pharmacognosy Magazine

ORIGINAL ARTICLE
Year
: 2010  |  Volume : 6  |  Issue : 22  |  Page : 102--105

Comparison of the cytotoxic effects of Juniperus sabina and Zataria multiflora extracts with Taxus baccata extract and Cisplatin on normal and cancer cell lines


M Shokrzadeh1, M Azadbakht2, N Ahangar1, H Naderi1, SS Saeedi Saravi1 
1 Department of Toxicology-Pharmacology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Mazandaran Pharmaceutical Sciences Research Center, Iran
2 Department of Pharmacognosy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Mazandaran Pharmaceutical Sciences Research Center, Iran

Correspondence Address:
M Shokrzadeh
18th Km of Khazarabad Road, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari
Iran

Isolation and identification of some potent anti-tumor compounds from medicinal plants has motivated researchers to screen different parts of plant species for the determination of anti-tumor effects. In this study, cytotoxic effects and IC 50 of specific concentrations of hydro-alcoholic extracts of fruits of Juniperus sabina and leaves of Zataria multiflora were compared with hydro-alcoholic extract of bark of Taxus baccata and Cisplatin, well-known anticancer compounds, on normal (CHO and rat fibroblast) and cancer (HepG2 and SKOV3) cell lines. The hydro-alcoholic extracts of the plants were prepared by percolation. The cytotoxic effects and IC 50 of the extracts on the cell lines were studied followed by colonogenic assay after 72 h incubation. The results showed that the extract of Juniperus sabina possesses lower IC 50 in comparison with Zataria multiflora extract on all 4 normal and cancer cell lines (P < 0.05); but, IC 50 of the Juniperus sabina extract was significantly higher than the Taxus baccata extract and Cisplatin on all 4 normal and cancer cell lines (P < 0.05). As a result, it is concluded that the extract of J. sabina has almost similar cytotoxicity with the extract of Taxus baccata on cancer cells.


How to cite this article:
Shokrzadeh M, Azadbakht M, Ahangar N, Naderi H, Saeedi Saravi S S. Comparison of the cytotoxic effects of Juniperus sabina and Zataria multiflora extracts with Taxus baccata extract and Cisplatin on normal and cancer cell lines.Phcog Mag 2010;6:102-105


How to cite this URL:
Shokrzadeh M, Azadbakht M, Ahangar N, Naderi H, Saeedi Saravi S S. Comparison of the cytotoxic effects of Juniperus sabina and Zataria multiflora extracts with Taxus baccata extract and Cisplatin on normal and cancer cell lines. Phcog Mag [serial online] 2010 [cited 2020 Apr 4 ];6:102-105
Available from: http://www.phcog.com/article.asp?issn=0973-1296;year=2010;volume=6;issue=22;spage=102;epage=105;aulast=Shokrzadeh;type=0