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ORIGINAL ARTICLE
Year : 2020  |  Volume : 16  |  Issue : 69  |  Page : 303-310

D-carvone attenuates biochemical and molecular expression via oncogenic signaling in aryl hydrocarbon-induced hamster mucosal carcinogenesis


1 Department of Stomatology, Baoding First Central Hospital, Baoding, Hebei, China
2 Department of Stomatology, Affiliated Hospital of Hebei University, Baoding, Hebei, China

Correspondence Address:
Zhizheng Zhuang
Department of Stomatology, Affiliated Hospital of Hebei University, Baoding 071000, Hebei
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/pm.pm_302_19

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Background: Chemo prevention through nutritional constituents has appeared as an innovative methodology to control the oral cancer incidence. The main target of this research exists to explore the chemopreventive effect of D-carvone by way of biochemical and molecular prototype during 7,12-dimethylbenz[a]anthracene (DMBA)-stimulated hamsters mucosal carcinogenesis. Materials and Methods: Topical application of 0.5% DMBA in liquid paraffin, thrice a week, for 10 weeks well developed oral squamous cell carcinoma in hamsters cheek pouch (HCP). All the same 100% tumor formation was perceived in hamsters induced with DMBA alone, but intragastric administration of D-carvone, at a dose of 10 mg/kg bw, to DMBA-treated hamster totally prevented the formation of oral tumor. Results: D-carvone significantly lessens lipid peroxidation (LPO) by-products and enhanced the status of enzymatic, non-enzymatic antioxidants, and varied the status of Phase I and II xenobiotic enzymes, favoring the secretion of cancer metabolites through downregulation of proliferating cell nuclear antigen and p53 expression during oral tumor hamsters. Conclusion: The nearby study suggests that D-carvone relies on its anti-LPO, antioxidant, xenobiotic metabolic enzymes as well as anti-cell proliferation and induced apoptosis during DMBA-induced hamster oral mucosal carcinogenesis.


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