Home | About PM | Editorial board | Search | Ahead of print | Current Issue | Archives | Instructions | Subscribe | Advertise | Contact us |  Login 
Pharmacognosy Magazine
Search Article 
  
Advanced search 
 
ORIGINAL ARTICLE
Year : 2020  |  Volume : 16  |  Issue : 69  |  Page : 282-287

Charantin relieves pain by inhibiting pro-inflammatory cytokine induction


1 Research Division of Food Functionality, Korea Food Research Institute, Wanju-Gun, Jeollabuk-Do, Korea
2 Research Division of Food Functionality, Korea Food Research Institute, Wanju-Gun, Jeollabuk-Do; Department of Food Biotechnology, Korea University of Science and Technology, Daejeon, Korea

Correspondence Address:
Yun Tai Kim
Research Division of Food Functionality, Korea Food Research Institute, 245, Nongsaengmyeong-Ro, Iseo-Myeon, Wanju-Gun, Jeollabuk-Do 55365, Department of Food Biotechnology, Korea University of Science and Technology, 217, Gajeong-Ro, Yuseong-Gu, Daejeon 34113
Korea
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/pm.pm_348_19

Rights and Permissions

Background: The fruits of Momordica charantia, commonly known as bitter melon, have been used as a traditional medicine in several countries. Some studies have reported its pharmacological effects in various disorders. Objectives: Because there have been little reports on charantin's role as an analgesic, we evaluated its pain relief effect to determine if it could be a novel pain killer candidate. Materials and Methods: We established post-operative and neuropathic pain models, which represent acute and chronic pain, respectively. Mechanical withdrawal threshold assay and ultrasonic vocalization analysis were used as behavioral tests. Results: The administration of charantin reduced both the post-operative and neuropathic pain. The application of charantin did not make a difference in the activation of action potentials of dorsal root ganglion (DRG) neurons. However, charantin inhibited the induction of the pro-inflammatory cytokines interleukin IL-12 and IL-1β in DRG neurons. Conclusion: Our findings indicate that charantin seems to relieve pain by inhibiting the inflammatory process rather than by directly influencing the activity of neurons. We conclude that charantin, the commercially available extract from M. charantia, has great efficacy as a novel analgesic compound.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed98    
    Printed6    
    Emailed0    
    PDF Downloaded28    
    Comments [Add]    

Recommend this journal