Home | About PM | Editorial board | Search | Ahead of print | Current Issue | Archives | Instructions | Subscribe | Advertise | Contact us |  Login 
Pharmacognosy Magazine
Search Article 
  
Advanced search 
 
ORIGINAL ARTICLE
Year : 2020  |  Volume : 16  |  Issue : 69  |  Page : 214-220

Fucoxanthin averts isoprenaline hydrochloride-induced myocardial infarction in rats


Department of Cardiology, Hanzhong Central Hospital, No.557, Middle Section of Labor West Road, Hantai District, Hanzhong City, Shaanxi Province, 723000, China

Correspondence Address:
Xianjun Wu
Department of Cardiology, Hanzhong Central Hospital, No. 557, Middle Section of Labor West Road, Hantai District, Hanzhong City, Shaanxi Province, 723000
China
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/pm.pm_357_19

Rights and Permissions

Background: In this current investigation, we aimed to assess the efficacy of natural antioxidant fucoxanthin against the myocardial infarction since it can be consumed as a regular diet. Objective: In this scientific investigation, we planned to investigate the curative effectual of fucoxanthin on isoprenaline hydrochloride provoked myocardial infarction on the experimental rats. Materials and Methods: Healthy Wistar albino rats were grouped into control, fucoxanthin alone, myocardial infarction induced, and myocardial infarction induced pretreated with fucoxanthin. The control rats were treated with a standard food diet, whereas fucoxanthin alone group rats were treated with 50 mg/kg/bwt of fucoxanthin along with standard diet. Myocardial infarction-induced groups were treated with 85 mg/kg/bwt of isoprenaline hydrochloride to induce myocardial infarction on the 29th and 30th days of the treatment period. Group IV rats were pretreated with 50 mg/kg/bwt of fucoxanthin from day 1 of experiment and on the 29th and 30th days of treatment period treated with 85 mg/kg/bwt of isoprenaline hydrochloride to induce myocardial infarction. Results: The fucoxanthin possessed effective cardioprotective activity in mycardiac infarction-induced rats. Fucoxanthin treatment reduced the statuses of cardiac troponin T and cardiac troponin I on myocardial infarction provoked rats; also, it exhibited the reduced Thiobarbituric acid reactive substances (TBARS) level in the rats. The antioxidant status such as superoxide dismutase, catalase, and glutathione peroxidase was extensively elevated in the myocardial infarction-induced fucoxanthin pretreated rats. Myocardial infarction-induced fucoxanthin pretreated rats shows decreased statuses of Na+/K+ ATPase and increase on the Na+/K+ ATPase level. Conclusion: Our results confirmed that fucoxanthin is a potent cardioprotective drug which increases the antioxidant levels and decreases the oxidative stress and inflammation during myocardial infarction.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed84    
    Printed7    
    Emailed0    
    PDF Downloaded37    
    Comments [Add]    

Recommend this journal