Home | About PM | Editorial board | Search | Ahead of print | Current Issue | Archives | Instructions | Subscribe | Advertise | Contact us |  Login 
Pharmacognosy Magazine
Search Article 
  
Advanced search 
 
ORIGINAL ARTICLE
Year : 2020  |  Volume : 16  |  Issue : 68  |  Page : 87-92

Antiobesity effects of lycii fructus in high-fat diet/fructose-induced obese rats


1 Department of Endocrinology, The First People's Hospital of Yunnan Province, Kunming, China
2 Department of Geriatrics, The Third People's Hospital of Yunnan Province, Kunming, China
3 Faculty of Traditional Thai Medicine, Prince of Songkla University, Hat Yai, 90110, Thailand

Correspondence Address:
Heng Su
Department of Endocrinology, The First People's Hospital of Yunnan Province, Kunming, Yunnan, 650032
China
Yan Wang
Department of Endocrinology, The First People's Hospital of Yunnan Province, Kunming, Yunnan, 650032
China
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/pm.pm_276_19

Rights and Permissions

Background: The prevalence of obesity is increasing at an enormous rate among all age groups which makes it one of the foremost health problems. Objective: This study was aimed at investigating the effect of the ethyl acetate extract from Lycii fructus (ETLF) against high-fat diet (HFD)/fructose-induced obesity in rats. Materials and Methods: Obesity was induced in rats by feeding them with HFD and 15% fructose for 8 weeks, while the animals in ETLF groups were administered with 100 and 400 mg/kg of ETLF once daily from the 5th to the 8th week. Results: ETLF displayed antiobesity by significantly reducing body weight gain, serum lipid levels as well as alleviating increased serum insulin and glucose levels. In addition, ETLF treatment when compared to the HFD/fructose fed group significantly alleviated oxidative stress and inflammation by reducing malondialdehyde, tumor necrosis factor alpha, interleukin 1 beta (IL-1 β) and IL-6 levels as well as enhancing the activities of superoxide dismutase, catalase, and glutathione peroxidase. Conclusion: Thus, these results portrayed that ETLF had protective effects against metabolic disorders induced by HFD/fructose through its antioxidant, anti-inflammatory, and antihyperlipidemic activities.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed193    
    Printed1    
    Emailed0    
    PDF Downloaded64    
    Comments [Add]    

Recommend this journal