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ORIGINAL ARTICLE
Year : 2019  |  Volume : 15  |  Issue : 62  |  Page : 34-37

In vitro antileishmanial activity of methanolic extracts for some selected medicinal plants


1 Department of Biochemistry, Faculty of Agriculture, Minia University, Minia, Egypt; Department of Pharmacognosy, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
2 Department of Pharmacognosy, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan; Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia, Egypt
3 Department of Pharmacognosy, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
4 Department of Pharmacognosy, Graduate School of Biomedical and Health Sciences, Hiroshima University; Department of Natural Products Chemistry, Faculty of Pharmacy, Yasuda Women's University, Hiroshima, Japan

Correspondence Address:
Ahmed Gomaa Gomaa Darwish
Department of Biochemistry, Faculty of Agriculture, Minia University, Minia 61519

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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/pm.pm_570_18

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Objective: The aim of this study is to evaluate the antileishmanial activity of selected medicinal plants; ten well-known medicinal plants cultivated and growing under African environmental conditions were studied. Materials and Methods: The methanolic extracts of these plants were screened for their antileishmanial activity against Leishmania major using 3-(4.5-dimethylthiazol-2yl)-2.5-diphenyltetrazolium bromide assay. Results: The methanol extract of Colchicum autumnale and Alpinia officinarum showed potent antileishmanial activity at inhibition% value of 98.29% ± 0.75% and 97.25 ± 1.63%, respectively, while Silybum marianum exhibited inhibition% value of 90.97% ± 1.13%, compared with the standard amphotericin B (89.31% ± 2.08%). Conclusion: Considering these results, medicinal plants from African environment could constitute a developer source for antileishmanial compounds.


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