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ORIGINAL ARTICLE
Year : 2019  |  Volume : 15  |  Issue : 61  |  Page : 283-289

Hepatoprotective and antioxidant potential of radish seed aqueous extract on cadmium-induced hepatotoxicity and oxidative stress in mice


1 College of Life Science and Bioengineering, Beijing University of Technology, Chaoyang, Beijing; Department of Food Quality and Safety, College of Food Science and Biotechnology, Tianjin Agricultural University, Xiqing, Tianjin, China
2 College of Life Science and Bioengineering, Beijing University of Technology, Chaoyang, Beijing, China
3 Department of Food Quality and Safety, College of Food Science and Biotechnology, Tianjin Agricultural University, Xiqing, Tianjin, China

Correspondence Address:
Yunjing Luo
Beijing Key Laboratory of Environmental and Viral Oncology, College of Life Science and Bioengineering, Beijing University of Technology, 100 Ping Le Yuan, Chaoyang District, Beijing 100124
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/pm.pm_365_18

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Background: Exposure to cadmium (Cd) is a major environmental pollutant that causes injury on many organs and tissues, particularly the liver. However, the protection of radish seed aqueous extract (RSE) against hepatic injury in Cd-exposed mice yet remains unclear. Objective: The research aimed to investigate the mitigation effect of RSE against Cd-induced hepatotoxicity in experimental animals. Materials and Methods: The mice were administered intraperitoneally with Cd Chloride (CdCl2, 75 mg/kg b. wt) as a positive control to compare RSE. The hepatic function and antioxidant status were assessed in liver tissue of poisoned and control mice. Results: Levels of serum hepatic enzymes (aspartate transaminase: AST and alanine transaminase: ALT) as well as total bilirubin were significantly increased in Cd-exposed mice. In addition, Cd exposure elicited enhancement of oxidative stress level. Co-treatment with RSE (200 and 400 mg/kg b. wt) significantly decreased the serum levels of liver function biomarkers. Furthermore, RSE treatment showed a significant reduction of lipid peroxidation and increase of enzyme and glutathione concentrations. Histopathological analysis was parallel to these biochemical findings. Conclusion: The results clearly demonstrated that RSE is effective for ameliorating hepatic cytotoxicity and oxidative damage arising from Cd exposure. Abbreviations used: Cd: Cadmium; ROS: Reactive oxygen species; RS: Radish seed; RSE: Radish seed aqueous extract; HPLC: High-performance liquid chromatography; SAE: Sulforaphene; SFE: Sulforaphene; TFC: Total flavonoids content; TPC: Total phenolics content; AST: Glutamic-oxalacetic transaminase; ALT: Glutamic pyruvic transaminase; TB: Total bilirubin; MDA: Malondialdehyde; CAT: Catalase; GPX: Glutathione peroxidase; NOx: Nitrates and nitrites; NO: Nitric oxide; LRS: Low dose of radish seed extract; HRS: High dose of radish seed extract; LPO: Lipid peroxidation; ONOO: Peroxynitrite radical; iNOS: Nitric oxide synthase.


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