Home | About PM | Editorial board | Search | Ahead of print | Current Issue | Archives | Instructions | Subscribe | Advertise | Contact us |  Login 
Pharmacognosy Magazine
Search Article 
  
Advanced search 
 
ORIGINAL ARTICLE
Year : 2019  |  Volume : 15  |  Issue : 61  |  Page : 244-252

Ameliorative effect of Sargassum fusiforme polysaccharides on oxidative stress and inflammation in ethanol-induced gastric ulcer


1 Department of Emergency, Jingyang People's Hospital, Xianyang, Shaanxi, China
2 Department of Hepatobiliary Thoracic Surgery, Jingyang People's Hospital, Xianyang, Shaanxi, China
3 Department of General Surgery, Jingyang People's Hospital, Xianyang, Shaanxi, China
4 Department of Digestive and Respiratory Medicine, Jingyang People's Hospital, Xianyang, Shaanxi, China

Correspondence Address:
Xiaojia Li
Department of Digestive and Respiratory Medicine, Jingyang People's Hospital, No. 116, Beijigong Street, Jingyang District, Xianyang City, Shaanxi 713700
China
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/pm.pm_457_18

Rights and Permissions

Background: Gastric ulcer is also known as stomach ulcer which is complex with multifactor-associated disease and shows high prevalent worldwide. It affects most of the people around the world, and the initiation and progression of the disease are due to the imbalance in the destructive and defensive mechanism and associated factors present in the mucosa of gastric. The current study is interested to evaluate the ethanolic extract of Sargassum fusiforme polysaccharides (SFPee) toward gastric ulcer induced by ethanol in rat model. Materials and Methods: S. fusiforme is a Chinese pharmacopeia and used as a medicinal ingredient. It contains polysaccharides, phlorotannins, and meroterpenoids which are the major contributors for its pharmacological properties. While the polysaccharides are the predominant ingredients, which account for 40%–60% of the algae dry weight. S. fusiforme polysaccharides show a potent antioxidation, anticancer, antiaging, and anticlotting function and thus promote health benefits. However, the mechanisms behind its pharmacological properties remain largely unknown. Here, we assessed the SFPee ameliorative effects on gastric ulcer induced by ethanol in male Wistar rats. We are also interested to identify the molecular machinery involvement of antigastric ulcer property of SFPee in gastric ulcer-induced rats. Results: Based on the investigation, the role of SFPee on gastric ulcer on various molecules, oxidative stress markers, antioxidant enzymes, the expression of nuclear factor-kappa B, IκB, nitrotyrosine, cyclooxygenase-2, and the assessment of the inflammatory response. Conclusion: Our results show that SFPee exhibited significant anti-inflammatory and antioxidant properties against ethanol-induced gastric ulcer by altering various molecules involved in the gastric ulcer initiation. Abbreviations used: SFP: Sargassum fusiforme polysaccharides; CAT: Catalase; SOD: Superoxide dismutases; ROS: Reactive oxygen species; TBARS: Thiobarbituric acid reactive substances.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed206    
    Printed3    
    Emailed0    
    PDF Downloaded0    
    Comments [Add]    

Recommend this journal