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ORIGINAL ARTICLE
Year : 2018  |  Volume : 14  |  Issue : 59  |  Page : 539-545

Hypoglycemic effect of ethyl acetate fraction of methanol extract from Campylandra aurantiaca rhizome on high-fat diet and low-dose streptozotocin-induced diabetic rats


1 Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal, India
2 Department of Pharmacology, Guru Nanak Institute of Pharmaceutical Science and Technology, Kolkata, West Bengal, India; Department of Pharmacology, Faculty of Health Science, University of the Free State, Bloemfontein 9031, South Africa
3 West Bengal Medical Services Corporation Ltd, Kolkata, West Bengal, India

Correspondence Address:
Pallab Kanti Haldar
Department of Pharmaceutical Technology, Jadavpur University, Kolkata - 700 032, West Bengal
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/pm.pm_194_17

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Background: Campylandra aurantiaca (Asparagaceae), commonly known as Nakima in Sikkimese Tibetan, is a plant grown in South-Central China and Northeast India. Objective: To evaluate the hypoglycemic activity of ethyl acetate fraction of methanol extract from C. aurantiaca rhizome (EFCA) in high-fat diet (HFD) and low-dose streptozotocin (STZ)-induced diabetic Wistar rats. Materials and Methods: In rats fed with HFD for 4 weeks, hyperglycemia was induced by single intraperitoneal injection of STZ (35 mg/kg body weight). Seven days after STZ induction, the hyperglycemic rats were treated with EFCA orally at the doses of 100 and 200 mg/kg b.w. daily for 28 days. Glibenclamide (0.5 mg/kg, orally) was used as reference drug. The fasting blood glucose levels were measured on every 7th day during the 28 days of treatment. Serum and hepatorenal biochemical parameters were estimated. Histological study of the pancreas was also performed. Results: EFCA at the doses of 100 and 200 mg/kg orally significantly (P < 0.05) and dose dependently reduced and normalized blood glucose levels as compared to that of STZ control group. Serum and hepatorenal parameters were significantly (P < 0.05) restored toward normal levels in EFCA-treated rats as compared to HFD-STZ control animals. Conclusion: The present study concludes that C. aurantiaca rhizome demonstrated promising hypoglycemic action in HFD-STZ-induced diabetic rats. Abbreviations used: IDDM: Insulin-dependent diabetes mellitus, T2DM: Type 2 diabetes mellitus, NIDDM: Noninsulin-dependent diabetes mellitus, T1DM: Type 1 diabetes mellitus, IDF: International Diabetes Federation, STZ: Streptozotocin, EFCA: Ethyl acetate fraction of methanol extract from Campylandra aurantiaca rhizome, OGTT: Oral glucose tolerance test, HFD: High-fat diet, FBG: Fasting blood glucose, HDL: High-density lipoprotein cholesterol, HbA1c: Glycosylated hemoglobin, AST: Aspartate transaminase, ALT: Alanine transaminase, ALP: Alkaline phosphatase, LPO: Lipid peroxidation, GSH: Reduced glutathione, SOD: Superoxide dismutase, CAT: Catalase, SEM: Standard error of mean, ANOVA: Analysis of variance, HPLC: High-performance liquid chromatography.


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