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ORIGINAL ARTICLE
Year : 2018  |  Volume : 14  |  Issue : 59  |  Page : 507-514

Neuropharmacological effects of methanolic extract of Clerodendrum viscosum leaves on wistar albino rats


1 Department of Pharmacology, Institute of Medical Sciences, Siksha ‘O’ Anusandhan University, Bhubaneswar, Odisha, India
2 Department of Pharmacology, KPC Medical College, WBUHS, Kolkata, West Bengal, India
3 Department of Pharmacognosy, School of Pharmaceutical Sciences, S‘O’A University, Bhubaneswar, Odisha, India
4 Regional Institute of Planning Applied Economics and Statistics, Government of Odisha, Bhubaneswar, Odisha, India

Correspondence Address:
Ayon Bhattacharya
Department of Pharmacology, KPC Medical College, 1F, Raja Subodh Chandra Mullick Road, Jadavpur, Kolkata - 700 032, West Bengal
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/pm.pm_267_18

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Background: The aim is to study the central nervous system (CNS) depressant, anxiolytic, and antiepileptic activities of methanolic extract of Clerodendrum viscosum (MECV) leaves. Materials and Methods: The study comprised five groups each with 6 Wistar albino rats. The Group 1 or the positive control (phenytoin 30 mg/kg for the epilepsy model, and diazepam 1 mg/kg for the other models), Group 2 or negative control (0.9% NaCl at 10 ml/kg), and Groups 3–5 or the test drug group (MECV at 200, 400, and 800 mg/kg). Actophotometer test, staircase test, maximal electroshock seizure (MES) test, and the thiopentone sodium-induced sleep test, were used to study the various parameters. Results: The actophotometer test, MES, and staircase test (steps climbed) were analyzed using parametric tests. The sleep induction and staircase test (number of rears) were evaluated using nonparametric tests. A dose-dependent significant (P < 0.05) response was observed in the actophotometer test, sleep induction, and MES tests in comparison to control. In the staircase test at 200 and 400 mg/kg, increase in the number of steps climbed, and at 800 mg/kg decrease in both the number of steps climbed and rears were observed in comparison to control. Conclusion: MECV showed a dose-dependent CNS depressant action in the sleep induction and antiepileptic tests. A CNS stimulant action was observed at low dose (200 mg/kg) and depressant action at a higher dose (800 mg/kg) in the staircase test in comparison to control. Abbreviations used: GLP: Good laboratory practice; CPCSEA: Committee for the Purpose of Control and Supervision of Experiments on Animals; IAEC: Institutional Animal Ethical Committee; CNS: Central nervous system; BZDs: Benzodiazepines; IP: Intraperitoneal ANOVA: Analysis of variance; MECV: Clerodendrum viscosum; HLE: Hind limb extension; HLF: Hind limb flexion; NMDA: N-methyl-D-aspartate; MES: Maximal electroshock seizures; MECV: Methanolic extract of Clerodendrum viscosum; GABA: Gamma-Aminobutyric acid; CCK: Cholecystokinin; PME: Pseudospondias microcarpa; ECG: Electrocardiography; REM: Rapid eye movement; NREM: Nonrapid eye movement.


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