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ORIGINAL ARTICLE
Year : 2017  |  Volume : 13  |  Issue : 50  |  Page : 370-374

Anti-lipid potential of Drimys brasiliensis


College of Pharmacy, Institute of Biological Sciences, University of Passo Fundo, Passo Fundo, Brazil

Correspondence Address:
Charise Dallazem Bertol
Curso de Farmácia, Instituto de Ciências Biológicas, Universidade de Passo Fundo, BR - 285, Bairro São José-Passo Fundo, RS
Brazil
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/pm.pm_306_16

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Background: The traditional use of Drimys brasiliensis Miers (Winteraceae) in the south of Brazil to reduce cholesterol has not been described in scientific literature. Objective: To verify the hypocholesterolemic effects of D. brasiliensis using rats as animal model. Materials and Methods: The bark of D. brasiliensis was extracted with water with further lyophilization and was subjected to phytochemical analysis by high-performance liquid chromatography (HPLC), and free radical scavenging activities by 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay to determine antioxidant potential. The hypocholesterolemic activity was determined in male Wistar rats treated with 100 and 250 mg/kg/day extract concomitantly fed a hypercaloric diet, over 20 days (prevention assay). In the treatment assay, rats were fed a hypercaloric diet for 40 days and received the extract (100 mg/kg/day) from day 20. Results: In this research, we found that the extract of the bark of D. brasiliensis was able to reduce the triglycerides significantly and reduce total cholesterol at doses 100 and 250 mg/kg/day and both administration regimens (prevention and treatment) in rats treated with the extract and hypercaloric diet. The extract showed strong antioxidant properties (DPPH assay), probably responsible by hypocholesterolemic activity of the plant. By HPLC, we detected catechin (1.34%), epicatechin (3.48%), rutin (0.86%), caffeic acid (0.45%), and ferulic acid (0.84%) in D. brasiliensis extract. Conclusions: We confirm the popular use of the plant to reduce of cholesterol. Abbreviations used: HPLC: High-performance liquid chromatography; PDA: Photodiode array detector; RS: Reference substances; DPPH: 1,1-diphenyl-2-picrylhydrazyl; VCEAC: Vitamin C equivalent antioxidant capacity.


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