Home | About PM | Editorial board | Search | Ahead of print | Current Issue | Archives | Instructions | Subscribe | Advertise | Contact us |  Login 
Pharmacognosy Magazine
Search Article 
  
Advanced search 
 
ORIGINAL ARTICLE
Year : 2017  |  Volume : 13  |  Issue : 50  |  Page : 354-358

Catha edulis Forsk. (Khat): Evaluation of its antidepressant-like Activity


1 Department of Pharmacology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia
2 Substance Abuse Research Centre, Jazan University, 11420, Jazan, Saudi Arabia
3 Medical Research Centre, Jazan University, 11420, Jazan, Saudi Arabia
4 Medical Research Centre, Jazan University, 11420, Jazan, Saudi Arabia; Department of Microbiology and Immunology, National Research Center, Dokki, Giza, Egypt
5 Natural Products Unit, King Fahd Medical Research Centre, King Abdulaziz University, Jeddah, Saudi Arabia

Correspondence Address:
Siddig Ibrahim Abdelwahab
Substance Abuse Research Centre, Jazan University, 11420, Jazan
Saudi Arabia
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/pm.pm_442_16

Rights and Permissions

Background: Catha edulis Forsk. (Khat) is traditionally used for treating various disorders. Nevertheless there are no reports of any scientific assessment of its psychopharmacological properties. Objective: Therefore, the current study was designed to evaluate the antidepressant-like activity of Khat ethanolic extract using established animal models of depression and stress. Materials and Methods: Ninety healthy male albino mice were used in this study. Forced swim, tail suspension and head poking tests were utilized to evaluate the antidepressant-like activity of the ethanolic extract of Khat (100, 200 and 400 mg/kg, i.p.) and escitalopram (standard drug) which were administered 30 min prior to the tests. Phytochemical analysis of the standardized extract was conducted using liquid chromatography-mass spectroscopy (LC-MS). Results: A significant decrease in the head-dipping behavior was noticed after administration of 100, 200 and 400 mg/kg of Khat extract. Moreover, the extract significantly decreased the immobility time in tail suspension and forced swim tests. The presence of cathinone and cathine were detected in the extract using LC-MS. Conclusion: The current results suggest that the extract of Khat leaves has acute antidepressant properties and may have sedative effects. Abbreviations used: LC-MS: Liquid chromatography-mass spectroscopy; NIST: National institute of standard technology; SSRI: Serotonin reuptake inhibitors; FST: Forced swim test; TST: Tail suspension test.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1227    
    Printed17    
    Emailed0    
    PDF Downloaded16    
    Comments [Add]    

Recommend this journal