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ORIGINAL ARTICLE
Year : 2017  |  Volume : 13  |  Issue : 50  |  Page : 339-343

The possible pre -and post -UVA radiation protective effect of amaranth oil on human skin fibroblast cells


1 Laboratory of Cosmetology, The Faculty of Pharmacy with the Division of Medical Analytics, Medical University of Bialystok, Białystok, Poland
2 Laboratory of Medicinal Chemistry, The Faculty of Pharmacy with the Division of Medical Analytics, Medical University of Bialystok, Białystok, Poland
3 Laboratory of Organic Chemistry, The Faculty of Pharmacy with the Division of Medical Analytics, Medical University of Bialystok, Białystok, Poland

Correspondence Address:
Katarzyna Wolosik
Laboratory of Cosmetology, The Faculty of Pharmacy, Medical University of Bialystok, ul. Akademicka 3, 15-267 Bialystok
Poland
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/pm.pm_522_15

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Background: The health effects of Amaranth Oil (AO) are attributed to its specific chemical composition. That makes it an outstanding natural product for the prevention and treatment of ultraviolet (UV) irradiation-related pathologies such as sunburn, photoaging, photoimmunosuppression, and photocarcinogenesis. Most of the studies are taken on animal model, and there is a lack of research on the endogenous effect of AO on fibroblast level, where UVA takes it harmful place. Objective: The aim of this study was evaluation if AO can protect or abolish UVA exposure effect on human skin fibroblast. Materials and Methods: The 0.1% AO, 0.25% AO, and 0.5% AO concentration and irradiation for 15 min under UVA-emitting lamp were studied in various condition. In all experiments, the mean values for six assays ± standard deviations were calculated. Results: Pretreatment with various concentrations of AO was tested. The highest concentration of AO where cell survival was observed was 0.5%. Cytotoxicity assays provided evidence for pre- and post-UVA protective effect of 0.1% AO among three tested concentrations. The results also provide evidence that UVA has inhibitory effect on collagen biosynthesis in confluent skin fibroblast, but presence of 0.1% AO abolishes pre- and post-UVA effect comparing to other used AO concentration. The assessment results on DNA biosynthesis show the significant abolished post-UVA effect when 0.1% and 0.5% of AO were added. Conclusion: AO gives pre- and post-UVA protection in low concentration. This provides the evidence for using it not as a main protective factor against UV but as one of the combined components in cosmetic formulation. Abbreviations used: AO: Amaranth Oil.


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