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ORIGINAL ARTICLE
Year : 2017  |  Volume : 13  |  Issue : 50  |  Page : 226-229

Betulinic acid from Zizyphus Joazeiro bark using focused microwave-assisted extraction and response surface methodology


1 Department of Health, State University of Feira de Santana, Feira de Santana, Bahia, Brazil
2 Department of Organic Chemistry, Federal University of Bahia, Salvador, Bahia, Brazil

Correspondence Address:
Prof. Alexsandro Branco
Department of Health, State University of Feira de Santana, Feira de Santana, Bahia
Brazil
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1296.204565

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Background: The effect of the extraction time (min) and temperature (°C) on the yield of betulinic acid (BA) from Zizyphus joazeiro barks using focused microwave-assisted extraction was investigated. Materials and Methods: The ethyl acetate was used as extractor solvent because it was shown to provide a betulinic acid-clean extract. A full two-level statistical factorial design was applied to determine the important effects and interactions of these independent variables upon the yield of BA. Results: The conditions that produced the highest yield of BA were at temperature of 70°C and an extraction time of 15 min (3.33 mg per gram of plant). Conclusion: The BA has drawn attention due to its use as a raw material in the synthesis of active compounds against the Human Immunodeficiency Virus (HIV). Abbreviation used: BA: Betulinic acid; FMAE: Focused microwave assisted extraction; HPLC: High-performance liquid chromatography; RSD: Relative standard deviations.


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