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ORIGINAL ARTICLE
Year : 2017  |  Volume : 13  |  Issue : 49  |  Page : 33-36

Biosynthesis, characterization, and biological activities of iron nanoparticles using Sesamum indicum seeds extract


1 Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Multan, Pakistan
2 Atta-ur-Rehman School of Applied Biosciences (ASAB), National University of Science and Technology Islamabad, Pakistan
3 Department of Biotechnology and Microbiology, Sarhad University of Science and Information Technology Peshawar, Pakistan

Correspondence Address:
Dr. Syed Aun Muhammad
Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Bosan Road, Multan
Pakistan
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1296.203985

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Background: Iron nanoparticles (FeNPs) have got many biomedical and health applications because of biocompatible and nontoxic nature to humans. Objective: To synthesize the FeNPs using natural sources. Materials and Methods: In this study, simple and economical procedure was adopted for FeNPs synthesis. Sesame seeds were processed to obtain seed extract as a biological material for FeNPs production. FeNPs were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, and scanning electron microscopic. Results: The average diameter of these FeNPs was 99 nm. These nanoparticles showed significant anti-typhoid activity (30 mm zone of inhibition) as compared to ciprofloxacin (32 mm) as standard. Furthermore, in vitro alpha-amylase inhibitory assay also showed moderate antidiabetic activity with more than 50% inhibition. Conclusion: This study would be helpful in understanding of nanoparticles synthesis from natural sources and ultimately will be used as potential alternative therapeutic agents. Abbreviations used: FeNPs: Iron Nano Particles; SEM: Scanning Electron Microscopy; MIC: Minimum Inhibitory Concentration; S. indicum: Sesamum Indicum.


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