Home | About PM | Editorial board | Search | Ahead of print | Current Issue | Archives | Instructions | Subscribe | Advertise | Contact us |  Login 
Pharmacognosy Magazine
Search Article 
  
Advanced search 
 
ORIGINAL ARTICLE
Year : 2016  |  Volume : 12  |  Issue : 48  |  Page : 259-261

A new antifungal isocoumarin from the endophytic fungus Trichoderma Sp. 09 of Myoporum bontioides A. gray


Department of Applied Chemistry, College of Materials and Energy (Formerly College of Science), South China Agricultural University, Guangzhou, China

Correspondence Address:
Dr. Chunyuan Li
College of Materials and Energy, South China Agricultural University, Guangzhou
China
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1296.192204

Rights and Permissions

Background: Myoporum bontioides A. Gray is a commonly used medicinal plant in China. Recently, the chemical and bioactive investigations to the endophytic fungi of this plant have led to several new compounds with antimicrobial and cytotoxic activities. To find out more active molecules, the metabolites of an endophytic fungus, Trichoderma sp. 09 from the root of Myoporum bontioides were investigated. Materials and Methods: The metabolites were isolated by column chromatography on silica gel, and their structures were elucidated on the basis of spectroscopic analysis[one-dimensional (1D), two-dimensional (2D)-nuclear magnetic resonance (NMR), Mass spectrometry (MS)], and by comparison with the published data. The dilution method was used for the evaluation of antifungal activity. Results: Four metabolites were isolated and identified as: dichlorodiaportinolide (1), dichlorodiaportin (2), diaportinol (3), and diaportin (4). Compounds1 and 2 showed weak to high antifungal activities against Colletotrichum musae (Berk. and M. A. Curtis) Arx and Rhizoctonia solani Kühn, as compared with the positive control. Conclusions: Compound 1 was a new isocoumarin being worthy of consideration for the development and research of antifungal agents. Abbreviations used: IR: Infrared Radiation, HR-ESI-MS: High resolution electrospray ionization mass spectroscopy, LCMS-IT-TOF: Liquid chromatography mass spectroscopy-Ion trap-Time-of-flight, UV: Ultraviolet-visible, HMBC: Heteronuclear multiple bond correlation, NOE: Nuclear Overhauser effect.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1721    
    Printed35    
    Emailed0    
    PDF Downloaded17    
    Comments [Add]    

Recommend this journal