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ORIGINAL ARTICLE
Year : 2016  |  Volume : 12  |  Issue : 47  |  Page : 395-399

Evaluation of the genotoxicity and cytotoxicity of semipurified fractions from the Mediterranean brown algae, Dictyopteris membranacea


1 Faculté de Pharmacie, Université de Monastir, Monastir, Tunisia
2 Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B-2610 Wilrijk, Belgium
3 Toxicology Unit, O.D. Food, Medicines and Consumer Safety, Scientific Institute of Public Health, J. Wytsmanstraat 14, B-1050 Brussels, Belgium
4 Faculté de Pharmacie, Université de Monastir, Monastir, Tunisia; Department of Biomedical Sciences, University of Antwerp, Universiteitsplein 1, B-2610 Wilrijk, Belgium

Correspondence Address:
Najoua Akremi
Faculté de Pharmacie de Monastir, Rue Ibn Sina, Monastir
Tunisia
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1296.188318

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Dictyopteris membranacea, a species of Mediterranean brown algae,is believed to have potential pharmacological and nutritional applications. However, such potentials only make sense when devoid of any adverse health consequences. The present study should be seen in this context. It aimed at evaluating the genotoxicity and cytoxicity of its organic extract (F0) and semi purified fractions (F 4, F 5, and F 6).Extracts were tested using the bacterial Vitotox® test and micronucleus assay in different concentrations (from 1.25 μg/mL up to 100 μg/mL, depending on the test and the extract). Applied concentrations were based on a preliminary dose-finding test with the neutral red uptake assay. The results show that all extracts were not genotoxic in the presence or absence of a rat metabolic enzyme fraction (S9). This is encouraging and justifies further investigations on the therapeutic and other values of this algae.


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