Home | About PM | Editorial board | Search | Ahead of print | Current Issue | Archives | Instructions | Subscribe | Advertise | Contact us |  Login 
Pharmacognosy Magazine
Search Article 
  
Advanced search 
 
ORIGINAL ARTICLE
Year : 2016  |  Volume : 12  |  Issue : 47  |  Page : 165-170

New phytochemical constituent and bioactivities of Horwoodia dicksoniae and Rumex cyprius


1 Department of Natural Product and Complementary Medicine, Faculty of Pharmacy, Northern Border University, Rafha, Kingdom of Saudi Arabia; Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt
2 Department of Clinical Pharmacology, Faculty of Pharmacy, Northern Border University, Rafha, Kingdom of Saudi Arabia
3 Department of Biology, Faculty of Science and Arts, Northern Border University, Rafha, Kingdom of Saudi Arabia; Department of Botany and Microbiology, Faculty of Science, Minia University, Minia, Egypt
4 Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt

Correspondence Address:
Mohammed F Abdelwahab
Department of Natural Product and Complementary Medicine, Faculty of Pharmacy, NBU University, Rafha

Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1296.186348

Rights and Permissions

Background: Many plants growing in Saudi Arabia are used in folk medicine for treatment of several diseases. Objective: Information of the chemical constituents and biological activities of plants is desirable for the discovery of therapeutic agents and discovering the actual value of folkloric remedies. Materials and Methods: The compounds were isolated and purified using silica gel column chromatography and preparative high-performance liquid chromatography-diode array detector (HPLC-DAD) Method. The alcoholic extracts of these plants were evaluated for biological activities. Results: Isolation and characterization of 1-feruloyl-β-D-glucopyranoside (1) as well as new secondary metabolite tryptophan methyl ester (2) were isolated for the 1st time from the Horwoodia dicksoniae. The three flavones were isolated from Rumex cyprius identified as isoorientin (3), vitexin (4), and Cynarosid (5). The structures of these compounds were characterized by nuclear magnetic resonance and mass spectrometry analysis and comparing with literature. The compounds were isolated and purified using silica gel column chromatography and preparative HPLC-DAD Method. The alcoholic extracts of these plants were evaluated for antimicrobial activities against two Gram-positive bacteria, two Gram-negative bacteria, and four pathogenic fungi. Both plants showed good activities against Syncephalastrum racemosum and Streptococcus pneumoniae with minimal inhibitory concentrations (MICs) 0.98 and 1.95 μg/mL, respectively. H. dicksoniae showed good activity against Aspergillus fumigates with an MIC 1.95 μg/mL. The two extracts showed also effective free radical scavenging activities in the 1,1-diphenyl-2-picrylhydrazyl assay. H. dicksoniae exhibited remarkable cytotoxic activity against Human breast cancer mammary cancer cells-7, Human liver cancer human hepatoma carcinoma cells-2, and human lung carcinoma (A-549) cell lines. Conclusions: It was suggested that further work should be carried out to isolate, purify, and characterize the active constituents responsible for the activity of these plants. SUMMARY
  • New secondary metabolite Tryptophane methyl ester as well as 1-feruloyl-β-D-glucopyranoside were isolated for the first time from the HD.
  • Isoorientin, vitexin and Cynarosid were isolated from RC.
  • HD exhibited good activity against Aspergillus fumigates with an MIC 1.95 μg mL-1.
  • HD showed significant cytotoxic activity against Human breast cancer (MCF-7), Human liver cancer (HepG-2) and Human lung carcinoma (A-549) cell lines.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2343    
    Printed35    
    Emailed0    
    PDF Downloaded23    
    Comments [Add]    

Recommend this journal