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ORIGINAL ARTICLE
Year : 2016  |  Volume : 12  |  Issue : 46  |  Page : 371-378

The antioxidant potential of Azadirachta indica ameliorates cardioprotection following diabetic mellitus-induced microangiopathy


1 Department of Biotechnology, University Institute of Engineering and Technology, Panjab University, Chandigarh; Department of Biotechnology, Banasthali University, Banasthali, Rajasthan, India
2 Department of Biotechnology, Banasthali University, Banasthali, Rajasthan, India
3 Department of Biochemistry, IGNOU, New Delhi, India
4 Department of Biotechnology, University Institute of Engineering and Technology, Panjab University, Chandigarh, India

Correspondence Address:
Naveen Kumar Gupta
Biotechnology Branch, University Institute of Engineering and Technology, Panjab University, Chandigarh - 160 014
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1296.185772

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Background: Cardiac complications associated with diabetes mellitus have become major cause of concern. Antidiabetic drugs, with varied mode of action, are although available, apprehensions exist for their limited action or side effects upon prolonged use. Efforts are therefore inclined toward finding other alternatives. The present study was, thus, undertaken to evaluate the cardioprotective effect of Azadirachta indica(AI) on microangiopathic changes in rat model of diabetes. Materials and Methods: Diabetes was induced in male rats by single intraperitoneal injection of streptozotocin (60 mg/kg body weight). Seven days after glucose levels are stabilized, aqueous leaf extract of AI (ALE) (600 mg/kg1 body weight) was administered orally to diabetic animals every day for 7 days. Results: High blood glucose characterizing diabetes in these animals was found to show increased lipid peroxidation (LPO), altered antioxidant biomarkers together with microangiopathic alterations. The treatment of diabetic rats with ALE reduced the levels of blood glucose, LPO, and restored the activities of antioxidant enzyme. Light and transmission electron microscopic analysis revealed reduced necrotic areas and inflammation in tissue architecture of ALE treated heart in comparison to untreated diabetic group. Conclusion: AI provides cardioprotection by ameliorating oxidative stress in rat model of diabetic mellitus.


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