Home | About PM | Editorial board | Search | Ahead of print | Current Issue | Archives | Instructions | Subscribe | Advertise | Contact us |  Login 
Pharmacognosy Magazine
Search Article 
  
Advanced search 
 
ORIGINAL ARTICLE
Year : 2016  |  Volume : 12  |  Issue : 46  |  Page : 228-230

Life span and motility effects of ethanolic extracts from Sophora moorcroftiana seeds on Caenorhabditis elegans


1 Department of Immunology, School of Basic Medical Sciences, Lanzhou 730000, China
2 Department of Immunology, School of Basic Medical Sciences; Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province, Lanzhou University, Lanzhou 730000, China
3 Department of Microbiology, Medical College, Northwest University for Nationalities, Lanzhou 730000, China

Correspondence Address:
Kaizhong Dong
Department of Microbiology, Medical College, Northwest University for Nationalities, Lanzhou 730000
China
Xingming Ma
Department of Immunology, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000
China
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1296.182152

Rights and Permissions

Background: Sophora moorcroftiana is an endemic shrub species with a great value in folk medicine in Tibet, China. In this study, relatively little is known about whether S. moorcroftiana is beneficial in animals' nervous system and life span or not. Materials and Methods: To address this question, under survival normal temperature (25°C), S. moorcroftiana seeds were extracted with 95% ethanol, and Caenorhabditis elegans were exposed to three different extract concentrations (100 mg/L, 200 mg/L, and 400 mg/mL) from S. moorcroftiana seeds. Results: The 95% ethanolic extracts from S. moorcroftiana seeds could increase life span and slow aging-related increase in C. elegans and could not obviously influence the motility of C. elegans. Conclusion: Given these results by our experiment for life span and motility with 95% ethanolic extracts from S. moorcroftiana seeds in C. elegans, the question whether S. moorcroftiana acts as an anti-aging substance in vivo arises. SUMMARY
  • The 95% ethanolic extracts from S. moorcroftiana seeds have no effect on the life span in C. elegans when extract concentrations from S. moorcroftiana seeds <400 mg/L
  • The 400 mg/L 95% ethanolic extracts from S. moorcroftiana seeds could increase life span in C. elegans
  • The 95% ethanolic extracts from S. moorcroftiana seeds could not obviously influence the motility in C. elegans.
Abbreviation used: S. moorcroftiana: Sophora moorcroftiana; C. elegan: Caenorhabditis elegan; E. coli OP50: Escherichia coli OP50; DMSO: Dimethyl sulfoxide.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1140    
    Printed14    
    Emailed0    
    PDF Downloaded24    
    Comments [Add]    

Recommend this journal