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ORIGINAL ARTICLE
Year : 2016  |  Volume : 12  |  Issue : 45  |  Page : 57-63

Influence of chitosan nanoparticles as the absorption enhancers on salvianolic acid B In vitro and In vivo evaluation


1 Department of Pharmacy, The Suqian First Hospital, Suqian, Jiangsu 223800, China
2 Depratment of Pharmacy, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China

Correspondence Address:
Ke Liang
The First Affiliated Hospital of Soochow University, 188 Shizi Road, Suzhou, Jiangsu, 215006
China
Zeng-yong Jia
The Suqian First Hospital, 120 Suzhi Road, Suqian, Jiangsu, 223800
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1296.176047

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Background: Salvianolic acid B (SalB) represents the most abundant and bio-active phenolic constituent among the water-soluble compounds of Salvia miltiorrhiza. But the therapeutic potential of SalB has been significantly restricted by its poor absorption. Methods: In this study, chitosans (CS) and CS nanoparticles (NPs) with different molecular weights (MWs), which have influence on the absorption of SalB, was also investigated. Results: As a preliminary study, water-soluble CS with various MWs (3, 30, 50, and 100 kDa) was chosen. We investigated the MW-dependent Caco-2 cell layer transport phenomena in vitro of CS and NPs at concentrations (4 μg/ml, w/v). SalB, in presence CS or NPs has no significant toxic effect on Caco-2 cell. As the MW increases, the absorption enhancing effect of CS increases. However, as the MW decreases, the absorption enhancing effect of NPs increases. The AUC 0-∞ of the SalB-100 kDa CS was 4.25 times greater than that of free SalB. And the AUC 0-∞ of the SalB-3 kDa NPs was 16.03 times greater than that of free SalB. Conclusion: CS and NPs with different MWs as the absorption enhancers can promote the absorption of SalB. And the effect on NPs is better than CS.


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