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ORIGINAL ARTICLE
Year : 2015  |  Volume : 11  |  Issue : 44  |  Page : 732-739

Effects of the main active components combinations of Astragalus and Panax notoginseng on energy metabolism in brain tissues after cerebral ischemia-reperfusion in mice


1 Molecular Pathology Laboratory, Hunan University of Chinese Medicine; Key Laboratory of Hunan Province for Prevention and Treatment of Integrated Traditional Chinese and Western Medicine on Cardio Cerebral Diseases; Key Laboratory of Hunan Universities for Cell Biology and Molecular Techniques, Changsha, Hunan Province, China
2 Key Laboratory of Hunan Universities for Cell Biology and Molecular Techniques, Changsha, Hunan Province, China
3 Key Laboratory of Hunan Province for Prevention and Treatment of Integrated Traditional Chinese and Western Medicine on Cardio Cerebral Diseases, Changsha, Hunan Province, China

Correspondence Address:
Chang-Qing Deng
Medical College, Hunan University of Chinese Medicine, Xueshi Road No. 300, Hanpu Science and Technology Park, Yuelu District, Changsha 410208
China
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Source of Support: This study was supported by National Natural Science Foundation of China (No. 81102557), Doctoral Program Foundation of Higher Education of China (No. 20104323110001), Aid Project for Innovation Platform Open Fund of Hunan province university (No.11K050, No. 14K068), Key Project of Administration of traditional Chinese Medicine of Hunan province (No. 201301, 201508), General Project of Science and Technology Department of Hunan Province (No. 2014SK3001), General Project of Education Bureau of Hunan Province (No. 11C0963), Ministry of Education Key Laboratory Open Fund Eestablished by the Province and the Ministry (ZYNK201405)., Conflict of Interest: None


DOI: 10.4103/0973-1296.165572

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Background: Astragalus and Panax notoginseng are traditional Chinese medicines used for the treatments of cardio-cerebrovascular ischemic diseases, astragaloside IV (AST IV) and ginsenoside Rg1 (Rg1), ginsenoside Rb1 (Rb1), notoginsenoside R1 (R1) are their active components. Objective: The purpose of this work was to investigate the effect of AST IV combined with Rg1, Rb1, R1 on energy metabolism in brain tissues after cerebral ischemia-reperfusion in mice. Materials and Methods: C57BL/6 mice were randomly divided into 11 groups, treated for 3 days. At 1 h after the last administration, the model of cerebral ischemia-reperfusion injury was established, and brain tissues were detected. Results: All drugs increased the contents of adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP) and the level of total adenine nucleotides (TAN), the combinations increased energy charge (EC), the effects of four active components combination were better. The phosphorylation of AMP-activated protein kinaseα1/2 (p-AMPKα1/2) was increased in AST IV, R1, four active components combination, AST IV + Rg1 and AST IV + R1 groups, the increased effect of four active components combination was greater than that of the active components alone and AST IV + Rb1. All drugs increased glucose transporter 3 (GLUT3) mRNA and protein, and the increases of four active components combination were more obvious than those of the active components alone or some two active components combinations. Conclusion: Four active components combination of Astragalus and P. notoginseng have the potentiation on improving of energy metabolism, the mechanism underlying might be associated with promoting the activation of AMPKα1/2, enhancing the expression of GLUT3, thus mediating glucose into nerve cells, increasing the supply and intake of glucose.


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