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ORIGINAL ARTICLE
Year : 2015  |  Volume : 11  |  Issue : 44  |  Page : 619-624

Inhibitory effect of spirulina maxima on the azoxymethane-induced aberrant colon crypts and oxidative damage in mice


1 Department of Morphology, Genetics Laboratory, National School of Biological Sciences, National Polytechnic Institute, Av. Wilfredo Massieu s/n. Lindavista, D. F. 07738, Mexico
2 Department of Pharmacy, Preclinical Toxicology, National School of Biological Sciences, National Polytechnic Institute, Av. Wilfredo Massieu s/n. Lindavista, D. F. 07738, Mexico
3 Department of Physiology, National School of Biological Sciences, National Polytechnic Institute, Av. Wilfredo Massieu s/n. Lindavista, D. F. 07738, Mexico
4 Department of Cellular Biology, Center for Research and Advanced Studies, National Polytechnic Institute, Av. Instituto Politécnico Nacional 2508, San Pedro Zacatenco, D.F. 07360; Cathedra-CONACYT, Faculty of Medicine and Surgery, Autonomous University "Benito Juárez" of Oaxaca, Av. Universidad s/n, Exhacienda de Cinco Señores, Oaxaca de Juárez, 68120, Mexico
5 Department of Cellular Biology, Center for Research and Advanced Studies, National Polytechnic Institute, Av. Instituto Politécnico Nacional 2508, San Pedro Zacatenco, D.F. 07360, Mexico
6 Department of Conservation Medicine, Superior School of Medicine, National Polytechnic Institute, Plan de San Luis y Díaz Mirón s/n, Casco de Santo Tomás, D. F. 11340, Mexico

Correspondence Address:
Eduardo Madrigal-Bujaidar
Genetics Laboratory, Department of Morphology, National School of Biological Sciences, National Polytechnic Institute, Av. Wilfredo Massieu s/n. Lindavista, D.F. 07738
Mexico
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1296.172973

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Background: Spirulina maxima (Sm) is a cyanobacterium well known because of its high nutritive value, as well as its anti-inflammatory, anti-hyperlipidemic, antioxidant, and anti-genotoxic activities. Objective: To determine the capacity of Sm to inhibit the induction of aberrant colon crypts (AC), as well as the level of lipid peroxidation and DNA oxidative damage in mice treated with azoxymethane (AOM). Materials and Methods: Sm (100, 400, and 800 mg/kg) was daily administered to animals by the oral route during 4 weeks, while AOM (10 mg/kg) was intraperitoneally injected to mice twice in weeks 2 and 3 of the assay. We also included a control group of mice orally administered with distilled water along the assay, as well as other group orally administered with the high dose of Sm. Results: A significant decrease in the number of AC with the three tested doses of Sm, with a mean protection of 51.6% respect to the damage induced by AOM. Also, with the three doses of the alga, we found a reduction in the level of lipoperoxidation, as well as in regard to the percentage of the DNA adduct 8-hydroxy-2'- deoxyguanosine. Conclusion: Sm possesses anti-precarcinogenic potential in vivo, as well as capacity to reduce the oxidative damage induced by AOM.


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