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ORIGINAL ARTICLE
Year : 2015  |  Volume : 11  |  Issue : 44  |  Page : 496-500

Modulatory role of Shorea robusta bark on Glucose-metabolizing enzymes in diethylnitrosamine induced hepatocellular carcinoma in rats


1 Centre for Research and Development, Marudupandiyar College, Thanjavur, Tamil Nadu, India
2 Department of Chemistry, PRIST University, Thanjavur, Tamil Nadu, India
3 Department of Biochemistry, Marudupandiyar College, Thanjavur, Tamil Nadu, India

Correspondence Address:
A Kalaiselvan
Centre for Research and Development, PRIST University, Thanjavur, Tamil Nadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1296.168981

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Introduction: The modulations of glucose-metabolizing enzyme activities play a vital rolein the depletion of energy metabolism and leads to inhibition of cancer growth. Objective: To find the effect of shorearobusta bark extract on glucose-metbolizing enzymes in diethylnitrosamine (DEN) induced hepatocellular carcinoma rats. Materials and Methods: Biochemical evaluation of glucose metabolizing enzyme were done in before and after shorearobusta bark extract (500mg/kg) treatment in DEN induced rats. Results: A significant increasein the activities of the key glycolytic enzymes viz., hexokinase and phosphoglucoisomerase, with a significant decrease in the gluconeogenic enzymes glucose-6-phosphatase and fructose-1,6-bisphosphatasewere observed in HCC bearing rats, when compared with the control. Administration of shorearobusta extract caused a significant decrease in theactivities of glycolytic enzymes and an increase in the gluconeogenic enzymes activities to near normal values. Conclusion: The current findings suggest that the S. robusta extract has a definite modulating role on the key enzymes ofglucose-metabolism in HCC. The modulatory effect may be due to the phytoactive constituents present in the extract of S. robusta.


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