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ORIGINAL ARTICLE
Year : 2015  |  Volume : 11  |  Issue : 44  |  Page : 290-295

Selectivity of Pinus sylvestris extract and essential oil to estrogen-insensitive breast cancer cells Pinus sylvestris against cancer cells


1 Faculty of Pharmacy, Hue University of Medicine and Pharmacy, Hue University, Hue City, Vietnam, Vietnam
2 Institute of Biotechnology, The Vietnam Academy of Science and Technology, Hanoi, Vietnam, Vietnam
3 Institute of Chemistry, Tallinn University of Technology, Tallinn, Estonia, Estonia
4 Department of Pharmacy, University of Tartu, Tartu, Estonia, Estonia

Correspondence Address:
Ain Raal
Department of Pharmacy, University of Tartu, Nooruse 1, Tartu 50411
Estonia
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1296.166052

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Background: So far, the anticancer action of pine tree extracts has mainly been shown for the species distributed widely around the Asian countries. Objective: Therefore, this study was performed to examine the potential cytotoxicity of Scots pine (Pinus sylvestrisL.) native also to the European region and growing widely in Estonia. Materials and Methods: The cytotoxic activity of methanol extract and essential oil of Scots pine needles was determined by sulforhodamine B assay in different human cancer cell lines. Results: This needle extract was found to suppress the viability of several human cancer cell lines showing some selectivity to estrogen receptor negative breast cancer cells, MDA-MB-231(half maximal inhibitory concentration [IC50] 35 μg/ml) in comparison with estrogen receptor-positive breast cancer cells, MCF-7 (IC50 86 μg/ml). It is the strongest cytotoxic effect at all measured, thus far for the needles and leaves extracts derived from various pine species, and is also the first study comparing the anticancer effects of pine tree extracts on molecularly different human breast cancer cells. The essential oil showed the stronger cytotoxic effect to both negative and positive breast cancer cell lines (both IC50 29 μg/ml) than pine extract (IC50 42 and 80 μg/ml, respectively). Conclusion: The data from this report indicate that Scots pine needles extract and essential oil exhibits some potential as chemopreventive or chemotherapeutic agent for mammary tumors unresponsive to endocrine treatment.


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