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ORIGINAL ARTICLE
Year : 2015  |  Volume : 11  |  Issue : 42  |  Page : 93-101

Toxicological and biochemical studies on Schinus terebinthifolius concerning its curative and hepatoprotective effects against carbon tetrachloride-induced liver injury


1 Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, University of Suez Canal, Ismailia 41522, Egypt
2 Department of Biochemistry, Faculty of Veterinary Medicine, University of Suez Canal, Ismailia 41522, Egypt
3 Department of Pharmacology, Faculty of Veterinary Medicine, University of Suez Canal, Ismailia 41522, Egypt

Correspondence Address:
Dr. Waleed F Khalil
Departments of Veterinary Pharmacology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1296.157705

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Background: Recently, many efforts have been made to discover new products of natural origin which can limit the xenobiotic-induced hepatic injury. Carbon tetrachloride (CCl 4 ) is a highly toxic chemical that is widely used to study hepatotoxicity in animal models. Objective: The present study was conducted to investigate the curative and protective effects of Schinus terbenthifolius ethanolic extract against CCl 4 -induced acute hepatotoxicity in rats. Materials and Methods: S. terbenthifolius extract was orally administered in a dose of 350 mg dried extract/kg b.wt. before and after intoxication with CCl 4 for curative and protective experiments, respectively. A group of hepatotoxicity indicative enzymes, oxidant-antioxidant capacity, DNA oxidation, and apoptosis markers were measured. Results: CCl 4 increased liver enzyme leakage, oxidative stress, hepatic apoptosis, DNA oxidation, and inflammatory markers. Administration of S. terebinthifolius, either before or after CCl 4 intoxication, significantly decreased elevated serum liver enzymes and reinstated the antioxidant capacity. Interestingly, S. terebinthifolius extract inhibited hepatocyte apoptosis as revealed by approximately 20 times down-regulation in caspase-3 expression when compared to CCl 4 untreated group. On the other hand, there was neither protective nor curative effect of S. terebinthifolius against DNA damage caused by CCl 4 . Conclusion: The present study suggests that S. terebinthifolius extract could be a substantially promising hepatoprotective agent against CCl 4 toxic effects and may be against other hepatotoxic chemical or drugs.


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