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ORIGINAL ARTICLE
Year : 2015  |  Volume : 11  |  Issue : 42  |  Page : 404-409

Quercetin induces human colon cancer cells apoptosis by inhibiting the nuclear factor-kappa B Pathway


1 Anorectal Disease Center, The First Affiliated Hospital, Henan College of TCM, Zhengzhou 450000, China
2 Department of Hematological Malignancy, The Affiliated Hospital, Henan TCM Research Academy, Zhengzhou 450000, China

Correspondence Address:
Xiang-An Zhang
Anorectal Disease Center, The First Affiliated Hospital, Henan College of TCM, No. 19, Renmin Road, Zhengzhou 450000
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1296.153096

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Quercetin can inhibit the growth of cancer cells with the ability to act as chemopreventers. Its cancer-preventive effect has been attributed to various mechanisms, including the induction of cell-cycle arrest and/or apoptosis as well as the antioxidant functions. Nuclear factor kappa-B (NF-kB) is a signaling pathway that controls transcriptional activation of genes important for tight regulation of many cellular processes and is aberrantly expressed in many types of cancer. Inhibitors of NF-kB pathway have shown potential anti-tumor activities. However, it is not fully elucidated in colon cancer. In this study, we demonstrate that quercetin induces apoptosis in human colon cancer CACO-2 and SW-620 cells through inhibiting NF-kB pathway, as well as down-regulation of B-cell lymphoma 2 and up-regulation of Bax, thus providing basis for clinical application of quercetin in colon cancer cases.


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