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ORIGINAL ARTICLE
Year : 2014  |  Volume : 10  |  Issue : 40  |  Page : 477-482

The treatment of Uygur medicine Dracocephalum moldavica L on chronic mountain sickness rat model


1 Department of Cardiology, The first Teaching Hospital of Xinjiang Medical University, XinjiangDepartment of Cardiology, The first Teaching Hospital of Xinjiang Medical University, Xinjiang, China
2 Department of Cardiology, The first Teaching Hospital of Xinjiang Medical University, Xinjiang, China
3 Department of Drug Analysis, Xinjiang Medical University, Xinjiang, China
4 Department of Animal Experiment, Urumqi General Hospital of Lanzhou Military, 830011 Urumqi, Xinjiang, China

Correspondence Address:
Ainiwaer Aikemu
Department of Drug Analysis, Xinjiang Medical University,393 Xinyi Road, 830011 Urumqi, Xinjiang
China
Xiangyang Zhang
The first Teaching Hospital of Xinjiang Medical University, 393Xinyi Road, 830011 Urumqi, Xinjiang
China
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Source of Support: This research work was supported by the Xinjiang Uygur Autonomous Region cardiovascular research laboratory project (XJDX0903.2013.01), Conflict of Interest: None


DOI: 10.4103/0973-1296.141817

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Aim: Dracocephalum moldavica L, a traditional Uygur medicine, possesses some key cardiac activities. However, till date, no reports are available on the use of D. moldavica against chronic mountain sickness (CMS), which is a medical condition that affects the residents of high altitude. The present study was designed to explore the treatment efficacy of D. moldavica on CMS. Materials and Methods: 80 of the 100 Sprague Dawley rats enrolled were bred in simulated high altitude environment and the remaining 20 rats were kept in the plains. Water and alcohol extracts of D. moldavica were prepared. CMS rat model was prepared, and the rat hearts were removed for histopathological analysis. Blood samples were taken for hematological and biochemical analyses. Rat pulmonary artery pressure was determined to study the treatment efficacy. Results: In the CMS model group, the levels of interleukin-6 (IL-6), C-reactive protein (CRP), and malondialdehyde (MDA) were found to be significantly higher than the control group; while the concentrations of SOD and GSH-Px decreased. D. moldavica could improve these levels, decrease pulmonary artery pressure, and improve the cardiac pathological state. Conclusions: The study results show that IL-6, CRP, MDA, SOD and GSH-Px participate and mediate the formation of CMS and D. moldavica is found to possess noticeable effects on CMS. The present study explored the basics of high altitude sickness and laid the foundation for further progress of Uygur medicines on the treatment of altitude sickness. Further preclinical and clinical studies with more sample size are recommended.


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