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ORIGINAL ARTICLE
Year : 2014  |  Volume : 10  |  Issue : 39  |  Page : 661-667

Anti-cancer effects of Kochia scoparia fruit in human breast cancer cells


1 Department of Oral Pathology, School of Dentistry, Institute of Translational Dental Sciences, Gyeongnam, Korea
2 Division of Pharmacology, School of Korean Medicine, Pusan National University, Gyeongnam, Korea
3 Department of Herbology, College of Korean Medicine, Wonkwang University, Jeonbuk, Korea
4 Department of Oral Medicine, School of Dentistry, Dental Research Institute, Pusan National University, Gyeongnam, Korea

Correspondence Address:
Mi Heon Ryu
Department of Oral Pathology, School of Dentistry, Institute of Translational Dental Sciences, Pusan National University, 49 Busandaehak ro, Yangsan City, Gyeongnam, 626 870
Korea
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1296.139812

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Background: The fruit of Kochia scoparia Scharder is widely used as a medicinal ingredient for the treatment of dysuria and skin diseases in China, Japan and Korea. Especially, K. scoparia had been used for breast masses and chest and flank pain. Objective: To investigate the anti-cancer effect of K. scoparia on breast cancer. Materials and Methods: We investigated the anti-cancer effects of K. scoparia, methanol extract (MEKS) in vitro. We examined the effects of MEKS on the proliferation rate, cell cycle arrest, reactive oxygen species (ROS) generation and activation of apoptosis-associated proteins in MDA-MB-231, human breast cancer cells. Results: MTT assay results demonstrated that MEKS decreased the proliferation rates of MDA-MB-231 cells in a dose-dependent manner with an IC 50 value of 36.2 μg/ml. MEKS at 25 μg/ml significantly increased the sub-G1 DNA contents of MDA-MB-231 cells to 44.7%, versus untreated cells. In addition, MEKS induced apoptosis by increasing the levels of apoptosis-associated proteins such as cleaved caspase 3, cleaved caspase 8, cleaved caspase 9 and cleaved Poly (ADP-ribose) polymerase (PARP). Conclusion: These results suggest that MEKS inhibits cell proliferation and induces apoptosis in breast cancer cells and that MEKS may have potential chemotherapeutic value for the treatment of human breast cancer.


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