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ORIGINAL ARTICLE
Year : 2014  |  Volume : 10  |  Issue : 39  |  Page : 501-505

New steroidal saponin from Antigonon leptopus Hook. and Arn.


Institute of Chemistry, College of Science, University of the Philippines, Diliman, Quezon City 1101, Philippines

Correspondence Address:
Christine L Chichioco-Hernandez
Institute of Chemistry, College of Science, University of the Philippines, Diliman, Quezon City 1101
Philippines
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1296.139781

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Background: Antigonon leptopus Hook. and Arn., Polygonaceae (cadena de amor), is a herbal remedy for pain and gout-like symptoms in the Philippines. The methanol extract of A. leptopus have shown strong inhibitory action against xanthine oxidase. Objective: To isolate and identify the compound responsible for the xanthine oxidase inhibitory action. Materials and Methods: A bioassay-guided isolation scheme using an in vitro assay for the inhibition of xanthine oxidase was employed. The structure was established using spectroscopic analysis and chemical methods. Results: The isolated compound was determined to be a noncompetitive inhibitor of xanthine with an IC50 of 1.79 μg/mL. Conclusion: The isolated compound may represent a new class of xanthine oxidase inhibitors.


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