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ORIGINAL ARTICLE
Year : 2014  |  Volume : 10  |  Issue : 39  |  Page : 314-317

Antitumor effects of dammarane-type saponins from steamed Notoginseng


1 Department of Pharmacognosy, Liaoning University of Traditional Chinese Medicine, Dalian, China
2 Institute of Chemistry and Applications of Plant Resources, Dalian Polytechnic University, Dalian, China
3 Herbal Medicine Improvement Research Center, Korea Institute of Oriental Medicine, Daejeon, Korea
4 College of Pharmacy, Chungnam National University, Daejeon, Korea

Correspondence Address:
Young Ho Kim
College of Pharmacy, Chungnam National University, Daejeon 305 764
Korea
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1296.137372

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Six dammarane-type saponins were extracted from steamed Panax notoginseng. Their chemical structures were identified spectroscopically as ginsenosides Rh 1 (1), Rg 1 (2), 20 (S)-Rg 3 (3), 20 (R)-Rg 3 (4), Rb 3 (5), and Rb 1 (6). Compounds (0.1-10 μM) were tested for inhibition of tumor necrosis factor-α (TNF)-induced nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) luciferase reporter activity using a human kidney 293T cell-based assay. Ginsenoside Rb 3 (5) showed the most significant activity with an IC 50 of 8.2 μM. This compound also inhibited the induction of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) messenger Ribonucleic acid (mRNA) in a dose-dependent manner after HepG2 cells had been treated with TNF-α (10 ng/mL).


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