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ORIGINAL ARTICLE
Year : 2014  |  Volume : 10  |  Issue : 39  |  Page : 213-216

New Sesquiterpene and Polymethoxy-Flavonoids from Artemisia annua L


1 Department of Pharmacy, the First Affiliated Hospital of China Medical University, 155 Nanjing Street, Shenyang; Department of the First Clinical Pharmacy, School of Pharmacy, China Medical University, 92 Bei'er Road, Shenyang, China
2 Department of Natural Natural Chemistry, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang, China
3 Department of Pharmaceutics, Ningxia Medical University, Yinchuan, China
4 College of Life and Health Sciences, Department of Biochemistry and Molecular Biology, Northeastern University, Shenyang, 110819, China

Correspondence Address:
Yang Chu
Department of Pharmacy, the First Affiliated Hospital of China Medical University, 155 Nanjing Street, and Department of the First Clinical Pharmacy, School of Pharmacy, China Medical University, 92 Bei’er Road, Shenyang 110001
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1296.137359

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Our previous study revealed that the polymethoxy-flavonoids, as main components of Artemisia annua, could improve the antimalarial activity of Artemisinin. Here, we described the isolation, elucidation, constituent analysis, flavonoids enrichment of the extracts of A. annua. A total of 20 compounds were isolated including a new sesquiterpene (compound 12) and five (1, 5, 6, 7, 15) afforded for the first time from A. annua. The elucidation of eight flavonoids may be a useful phytochemical data and chemical foundation for further mechanism studies on improving the anti-malarial action of artemisinin. Furthermore, the antitumor activities of the compounds were assayed using four different kinds of human cancer cell lines.


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