Home | About PM | Editorial board | Search | Ahead of print | Current Issue | Archives | Instructions | Subscribe | Advertise | Contact us |  Login 
Pharmacognosy Magazine
Search Article 
  
Advanced search 
 
ORIGINAL ARTICLE
Year : 2013  |  Volume : 9  |  Issue : 36  |  Page : 290-293

Influence of the mixture of Epimedii Herba and Ginkgo Folium extracts on the coronary flow of isolated hearts in rats


School of Pharmaceutical Science, China Medical University, China

Correspondence Address:
DongFang Zhang
School of Pharmaceutical Science, China Medical University, No.92 Bei'er Road, Heping District, Shenyang City-110 001
China
Login to access the Email id

Source of Support: Natural Science Foundation of Liaoning Province (No. 2012010155-401)., Conflict of Interest: None


DOI: 10.4103/0973-1296.117816

Rights and Permissions

Background: In clinical practice, Epimedii Herba and Ginkgo Folium preparations are widely used in treatment of diseases such as coronary heart disease (angina) in China . However, there are no studies on the two-drug combination. Objective: To explore the effect of the mixture of the Epimedii Herba extract (EE) and Ginkgo Folium extract (GE) on coronary flow of isolated hearts in rats. Materials and Methods : EE and GE were prepared by reflux in alcohol, and processed with HPD-100 macro-reticular resins; icariin from EE and total bilobalides from GE were determined by high performance liquid chromatography (HPLC). Fifty male Sprague-Dawley (SD) mice were subdivided into five groups (10 rats each): Normal control group (NC), EE - 10 mg group, GE - 10 mg group, EE - 5 mg + GE - 5 mg group, and EE - 10 mg + GE - 10 mg group. Isolated hearts uniform pressure perfusion was proceeded with Langendorff system. Results: The content of icariin in EE was 20.8%. The total content including four kinds of bilobalides (ginkolide A-C and bilobalide) in GE was 8.6%. The coronary flow in the NC group remained stable before and after treatment, and the coronoray flow in the EE, GE, EE + GE groups was increased and the relative magnitude of heightening was 25.0-33.3%, and the coronary flow in EE + GE was significantly different from that in the single EE or GE group. Conclusion: EE or GE itself can heighten coronary flow of isolated hearts in rats. The activity of the mixture including EE and GE is better than that of single EE or GE, and the activity becomes larger when the dosage is doubled, and is related with dosage.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed4041    
    Printed57    
    Emailed1    
    PDF Downloaded22    
    Comments [Add]    

Recommend this journal