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ORIGINAL ARTICLE
Year : 2013  |  Volume : 9  |  Issue : 35  |  Page : 196-201

Interaction of lobed kudzuvine root, rhizoma chuanxiong with both acetylcholinesterase and beta-amyloid (Aβ1-42)


1 College of Pharmacy, South-Central University for Nationalities, Minyuan Road 708, Hongshan District, Wuhan, Hubei, 430074, China
2 Center of Analysis, Guangdong Medical College, Dongguan, 523808, China

Correspondence Address:
Li Shuai
Pharmacy College of South-Central, University for Nationalities, Wuhan, Hubei Province 430074
China
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Source of Support: The Special Fund for Basic Scientific Research of Central Colleges, South-Central University for Nationalities (CZQ12020)., Conflict of Interest: None


DOI: 10.4103/0973-1296.113262

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Background: Lobed kudzuvine root and rhizoma chuanxiong are effective drugs in traditional Chinese medicine. Objective: Extracts of the two medicines were investigated for their in vitro of beta-amyloid (Aβ1-42)-aggregation-and acetylcholinesterase (AChE)-inhibitory activities. Materials and Methods: The interaction of lobed kudzuvine root, rhizoma chuanxiong with both acetylcholinesterase and beta-amyloid (Aβ1-42) were studied by Michaelis-Menten equations, Thioflavin T (ThT) fluorescence analysis and transmission electron microscope (TEM). Results: Inhibition of acetylcholinesterase showed that 1-butanol fraction of the two medicines were noncompetitive inhibition, apparent inhibition constants were 9.947 and 7.1523. ThT fluorescence analysis and TEM results indicated that inhibition of the water fraction and 1-butanol fraction (both lobed kudzuvine root and rhizoma chuanxiong) was better. Conclusion: The result supported further research on chemical constituents and pharmacological mechanisms.


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