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ORIGINAL ARTICLE
Year : 2013  |  Volume : 9  |  Issue : 34  |  Page : 149-154

Nimodipine rescues N-methyl-N-nitrosourea-induced retinal degeneration in rats


1 Department of Histology and Embryology, College of Basic Medical Science, China Medical University, Liaoning Shenyang; Department of Pharmacology, HE's University, Liaoning Shenyang, China
2 Department of Physiology, Experimental Teaching Center of Pharmacology, School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Liaoning Shenyang, China
3 Department of Pharmacology, HE's University, Liaoning Shenyang, China
4 Department of Histology and Embryology, College of Basic Medical Science, China Medical University, Liaoning Shenyang, China
5 Department of Basic Pharmacology, Liaoning University of Traditional Chinese Medicine, Liaoning Shenyang, China

Correspondence Address:
Gui-yuan Sun
Department of Histology and Embryology, College of Basic Medical Science, China Medical University, Liaoning Shenyang
China
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Source of Support: China Medical University., Conflict of Interest: None


DOI: 10.4103/0973-1296.111276

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Background: That nimodipine (NMD) is potentially useful for ophthalmic treatment. However, the effect of NMD is unknown on retinal degenerative diseases. Objective: The purpose of the present study was to investigate the effect of NMD on N-methyl-N-nitrosourea (MNU)-induced retinal degeneration (RD) and elucidate its possible mechanisms. Materials and Methods: Morphological observation of NMD on MNU-induced RD was evaluated by light microscopy and electron microscopy. Nonenzymatic antioxidant glutathione (GSH) was measured by a colorimetric method. Transforming growth factor-beta (TGF-β) was measured by enzyme-linked immunosorbent assay (ELISA). Telomerase was detected by reverse transcriptase polymerase chain reaction (RT-PCR). Results: The significantly protective effect of NMD on MNU-induced RD was demonstrated morphologically. NMD increased the content of GSH and decreased the level of TGF-β in rat retina. RT-PCR analysis demonstrated that NMD treatment significantly decreased mRNA level of telomerase. Conclusion: These data suggest that NMD inhibit MNU-induced RD in rats. The expressions of TGF-β, telomerase and GSH contents might partially contribute to its protective effects on MNU-induced RD.


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