Home | About PM | Editorial board | Search | Ahead of print | Current Issue | Archives | Instructions | Subscribe | Advertise | Contact us |  Login 
Pharmacognosy Magazine
Search Article 
  
Advanced search 
 
ORIGINAL ARTICLE
Year : 2012  |  Volume : 8  |  Issue : 31  |  Page : 192-196

Postprandial blood glucose response to grape seed extract in healthy participants: A pilot study


1 The Medical Food Research and Development Center, Department of Nutrition and Dietetics, Faculty of Allied Health Science, Chulalongkorn University, Bangkok; Research Group of Herbal Medicine for Prevention and Therapeutic of Metabolic diseases, Chulalongkorn University, Bangkok, Thailand
2 Undergraduate Program in Nutrition and Dietetics, Faculty of Allied Health Sciences, Chulalongkorn University, 154 Rama I Road, Wangmai Pathumwan, Bangkok 10330, Thailand

Correspondence Address:
Suwimol Sapwarobol
Faculty of Allied Health Science, Chulalongkorn University, 154 Rama I Road, Wangmai Pathumwan, Bangkok 10330
Thailand
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1296.99283

Rights and Permissions

Background: The consumption of a high carbohydrate diet may be associated with an increased risk of type 2 diabetes and obesity. Previous studies in vitro have revealed that grape seed extract (GSE) inhibited the intestinal α-glucosidases and α-pancreatic amylase that may delay carbohydrate digestion and absorption, resulting in the suppression of postprandial glycemia. The objective of the study was to assess whether consumption of GSE together with high carbohydrate meal affects postprandial glycemia in healthy participants. Materials and Methods: The study used acute, randomized, controlled crossover design in which eight healthy subjects (four female and four male, mean aged 21.25 ± 3.69 years; body mass index =20.28 ± 1.40 kg/m 2 ) received high carbohydrate (HC) meal (73.6 %) together with or without 100 and 300 mg GSE. Results: Results showed that postprandial plasma glucose concentrations at 15 min and 30 min after ingestion HC meal together with 100 mg GSE (5.33 ± 0.41 mmol/L and 5.62 ± 0.47 mmol/L, respectively) and 300 mg GSE (5.27 ± 0.29 mmol/L; 5.75 ± 0.44 mmol/L, respectively) were significantly lower than that of HC meal (P<0.05). There was statistically significant difference in the 2 h area under the glucose response curve between HC meal and HC meal plus GSE. Conclusions: GSE reduces postprandial plasma glucose in healthy participants. The delayed and attenuated hyperglycemia may have a useful strategy to prevent development of diabetes in the healthy population.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2960    
    Printed171    
    Emailed3    
    PDF Downloaded17    
    Comments [Add]    
    Cited by others 7    

Recommend this journal