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ORIGINAL ARTICLE
Year : 2012  |  Volume : 8  |  Issue : 30  |  Page : 98-102

Chemical constituents with free-radical-scavenging activities from the stem of Fissistigma polyanthum


1 Department of Natural Products, College of Pharmacy, South Central University for Nationalities, Wuhan, P.R., China
2 College of Chemistry and Material Sciences, South Central University for Nationalities, Wuhan, P.R, China

Correspondence Address:
Guang-Zhong Yang
College of Pharmacy, South Central University for Nationalities, Wuhan 430074, P. R.
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1296.96549

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Background: Fissistigma polyanthum is a liane belonging to the Annonaceae family and it is one of the most important crude drugs in traditional Chinese medicine. Objective: The objective was to describe the structural elucidation and the free-radical-scavenging activities of the isolated compounds from Fissistigma polyanthum. Material and Methods: The chemical constituents were isolated and purified by normal, reverse column chromatography and HPLC. Their structures were identified by spectroscopic methods ( 1 H NMR and 13 C NMR) and by comparison with literature values, and the free-radical-scavenging activities of these two compounds were also evaluated through three in vitro model systems (DPPH, trolox equivalent antioxidant capacity (TEAC) and Co (II) EDTA-induced luminol chemiluminescence by flow injection). Results: Two known compounds, named kanakugiol (1) and teutenone A (2), were isolated from the stem of Fissistigma polyanthum for the first time, and compound 1 exhibited moderate free-radical-scavenging activity. Conclusion: Fissistigma polyanthum, which has traditionally been used as an important Chinese medicine, showed a certain free-radical-scavenging activity.


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