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ORIGINAL ARTICLE
Year : 2011  |  Volume : 7  |  Issue : 28  |  Page : 284-288

Neuroprotective activity of the methanolic extract of Lonicera japonica in glutamate-injured primary rat cortical cells


1 Department of Biomaterials Engineering, School of Bioscience and Biotechnology, Kangwon National University, Chuncheon, Korea
2 Department of Biomaterials Engineering, School of Bioscience and Biotechnology, Kangwon National University, Chuncheon; Research Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon 200-701, Korea

Correspondence Address:
Choong Je Ma
Department of Biomaterials Engineering, Division of Biotechnology and Bioengineering, Kangwon National University, Hyoja-2 Dong, Chuncheon 200-701
Korea
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Source of Support: Grant of the Korean Ministry of Education, Science and Technology (The Regional Core Research Program/Medical & Bio-Material Research Center), Conflict of Interest: None


DOI: 10.4103/0973-1296.90404

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Background: We previously reported that the extracts of several Korean medicinal plants showed neuroprotective activity in glutamate-injured primary culutres of rat cortical cells. Objective: Among them, the effect of the methanolic extract of Lonicera japonica flower on the glutamate-induced neuronal cell death and its potential mechanism of action was investigated. Results: Treatment by the methanolic extract of L. japonica flower significantly protected neuronal cells against glutamate-induced excitotoxicity. It decreased the calcium influx that accompanies the glutamate induced excitotoxicity of neuronal cells, and inhibited the subsequent overproduction of nitric oxide, reactive oxygen species and peroxide to the level of control cells. In addition, it preserved cellular activity of superoxide dismutase, an antioxidative enzyme reduced by glutamate insult. Conclusions: According to this data, the methanolic extract of L. japonica flower significantly protected neuronal cells against glutamate excitotoxicity via antioxidative activity.


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